Detecting inflammation with 131I-labeled ornidazole
| dc.contributor.author | Asikoglu M. | |
| dc.contributor.author | Yurt F. | |
| dc.contributor.author | Cagliyan O. | |
| dc.contributor.author | Unak P. | |
| dc.contributor.author | Ozkilic H. | |
| dc.date.accessioned | 2019-10-27T09:00:15Z | |
| dc.date.available | 2019-10-27T09:00:15Z | |
| dc.date.issued | 2000 | |
| dc.department | Ege Üniversitesi | en_US |
| dc.description.abstract | The aim of this study was to demonstrate the accumulation of 131I-labeled ornidazole (131I-ORN) in experimental abscesses. 131I-ORN was prepared by electrophilic radioiodination of ORN, using radioiodide in the presence of Iodogen®. An in vivo inflammation model was prepared by intramuscular injection of turpentine into the thigh of rabbits. Four days later 131I-ORN was intravenously administered to rabbits. Serial scintigrams were performed at different periods, using a Sophy DX Gamma Camera. 131I-ORN was visualized at 10 min after injection. 131I-ORN was also administered intraperitoneally to rats with turpentine-induced inflammation, for quantitative biodistribution studies. Counts of selected tissues were taken by a NaI(Tl) scintillation detector (gamma counter) after rats were decapitated. The target-to-non-target muscle ratios were 2.5, 2.6, 2.9 and 1.9 at 1, 3, 5 and 24 h, respectively. Copyright (C) 2000 Elsevier Science Ltd. | en_US |
| dc.identifier.doi | 10.1016/S0969-8043(99)00150-5 | en_US |
| dc.identifier.endpage | 413 | en_US |
| dc.identifier.issn | 0969-8043 | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.pmid | 10972145 | en_US |
| dc.identifier.scopusquality | Q3 | en_US |
| dc.identifier.startpage | 411 | en_US |
| dc.identifier.uri | https://doi.org/10.1016/S0969-8043(99)00150-5 | |
| dc.identifier.uri | https://hdl.handle.net/11454/28025 | |
| dc.identifier.volume | 53 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Applied Radiation and Isotopes | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Detecting inflammation with 131I-labeled ornidazole | en_US |
| dc.type | Article | en_US |
