Diagnostic Accuracy of Interleukin-6, Interleukin-8, and Interleukin-10 for Predicting Bacteremia in Children with Febrile Neutropenia

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dc.contributor.authorBal, Zumrut Sahbudak
dc.contributor.authorOzdemir, Nihal Karadas
dc.contributor.authorSen, Semra
dc.contributor.authorKarapinar, Deniz Yilmaz
dc.contributor.authorAzarsiz, Elif
dc.contributor.authorAydemir, Sohret
dc.contributor.authorVardar, Fadil
dc.date.accessioned2019-10-27T11:05:59Z
dc.date.available2019-10-27T11:05:59Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractDespite improvements in diagnosis and treatment, infections are still a major cause of morbidity and mortality in children with febrile neutropenia. In the majority of febrile episodes, the source of infection cannot be defined. In this study, we aimed to identify the earlier predictors of bacteremia/fungemia and a useful cytokine to identify the source of infection and to discriminate the patients with culture-confirmed bacterial/fungal infection. The most sensitive cytokine was interleukin (IL)-10 and the most specific was IL-8 in predicting culture-confirmed cases. IL-8 had greater sensitivity and specificity in determination of gram-negative bacterial infections with a higher negative predictive value; therefore, IL-8 can be used particularly to rule out gram-negative bacterial infections. IL-6, IL-8, and IL-10 circulating levels were shown to be higher in cases of infection. Further studies are needed to recommend a routine practice for predicting culture-confirmed bacterial infections.en_US
dc.identifier.doi10.4274/tjh.2016.0434en_US
dc.identifier.endpage257en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue3en_US
dc.identifier.pmid28148470en_US
dc.identifier.startpage254en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.2016.0434
dc.identifier.urihttps://hdl.handle.net/11454/31781
dc.identifier.volume34en_US
dc.identifier.wosWOS:000410936000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFebrile neutropeniaen_US
dc.subjectIL-6en_US
dc.subjectIL-8en_US
dc.subjectIL-10en_US
dc.subjectBacteremiaen_US
dc.titleDiagnostic Accuracy of Interleukin-6, Interleukin-8, and Interleukin-10 for Predicting Bacteremia in Children with Febrile Neutropeniaen_US
dc.typeArticleen_US

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