Mitotyping of random bred cats and pure breed cats (Turkish Angora and Turkish Van) using non-repetitive mitochondrial DNA control region

Basit Öğe Kaydı
dc.authorscopusid56607300500
dc.authorscopusid57221117593
dc.authorscopusid7003392648
dc.authorscopusid23003351400
dc.authorscopusid25825299300
dc.authorscopusid57212213434
dc.authorscopusid23767084500
dc.contributor.authorBilgen, N.
dc.contributor.authorGüvendi, M.
dc.contributor.authorSezgin, E.
dc.contributor.authorCan, H.
dc.contributor.authorKöseoğlu, A.E.
dc.contributor.authorErkunt, Alak, S.
dc.contributor.authorDöşkaya, M.
dc.date.accessioned2024-08-25T18:36:15Z
dc.date.available2024-08-25T18:36:15Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThe Fertile Crescent appears to be the most plausible region where the domestication of cats commenced through a mutually beneficial relationship between wild cats and early agrarian societies. These domesticated cats then journeyed across the globe mirroring the paths of human migration. An examination of mitochondrial DNA (mtDNA) control region-based mitotyping suggested that a significant majority, exceeding 80%, of globally sampled random-bred and pure-bred cats could be categorized into 12 predominant mitotypes. However, the extent of mitotype diversity within random-bred cats from regions proximate to the Fertile Crescent remains inadequately explored. In light of this we aimed to investigate the mitotype diversity in random bred cats sampled from various regions across Turkey. Additionally, we sought to establish a comparison with the mitotype profiles of locally recognized pure breeds, namely the Turkish Angora and Turkish Van. To unravel their evolutionary narratives, we engaged in comprehensive population genetics analyses at both the individual and mitotype-based levels. Our study encompassed a sample size of 240 specimens, forming the basis for both mitotyping and population genetics scrutiny. Our analysis yielded the identification of nine ‘universal’ mitotypes (A—J), alongside an ‘outlier’ mitotype group I. Notably mitotypes A and D emerged as particularly prevalent in contrast to the lesser occurrence mitotypes C, G, and H. With the realm of random bred cats the structure of haplotypes exhibited remarkable diversity presenting distinctions from Turkish Angora and Van breeds. Nucleotide diversity was higher compared to previous reports from Turkey and was one of the highest among reported world cat population estimates. Intriguingly, our investigations did not unveil any pronounced instances of strong selection, population expansions or contractions within any specific population or mitotype. To conclude, our study represents a pioneering effort in uncovering the mitotype profiles and haplotype structures inherent to both random-bred and pure breed cats in Turkey. This endeavor not only broadens our understanding of the feline genetic landscape within the region but also lays the foundation for future inquiries into the evolutionary trajectories and genetic legacies of these feline populations. © 2023 Elsevier B.V.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 114O768, 218Z105en_US
dc.description.sponsorshipThis study was partially supported by a project given by the Scientific and Technological Research Council of Turkey (TÜBİTAK) (Project number: 218Z105) and another project given by the Scientific and Technological Research Council of Turkey (TÜBİTAK) (Project number: 114O768). The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.en_US
dc.identifier.doi10.1016/j.gene.2023.147849
dc.identifier.issn0378-1119
dc.identifier.pmid37776989en_US
dc.identifier.scopus2-s2.0-85173259418en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.gene.2023.147849
dc.identifier.urihttps://hdl.handle.net/11454/100573
dc.identifier.volume892en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofGeneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectMitotypingen_US
dc.subjectmtDNA CRen_US
dc.subjectSequencingen_US
dc.subjectTurkeyen_US
dc.subjectmitochondrial DNAen_US
dc.subjectnucleotideen_US
dc.subjectanimal experimenten_US
dc.subjectArticleen_US
dc.subjectcat breeden_US
dc.subjectclassificationen_US
dc.subjectcontrolled studyen_US
dc.subjectDNA sequencingen_US
dc.subjectgenetic analysisen_US
dc.subjectgenetic proceduresen_US
dc.subjectgenetic profileen_US
dc.subjectgenetic variabilityen_US
dc.subjecthaplotypeen_US
dc.subjectlocus control regionen_US
dc.subjectmitotypeen_US
dc.subjectmitotypingen_US
dc.subjectmolecular evolutionen_US
dc.subjectnonhumanen_US
dc.subjectpopulation geneticsen_US
dc.subjectprevalenceen_US
dc.subjectpurebred caten_US
dc.subjectrandom sampleen_US
dc.subjectsample sizeen_US
dc.subjectTurkey (republic)en_US
dc.subjectTurkish Angoraen_US
dc.subjectTurkish Vanen_US
dc.titleMitotyping of random bred cats and pure breed cats (Turkish Angora and Turkish Van) using non-repetitive mitochondrial DNA control regionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu