Frequency of Mycobacterium bovis and mycobacteria in primary immunodeficiencies

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dc.contributor.authorUlusoy, Ezgi
dc.contributor.authorKaraca, Neslihan Edeer
dc.contributor.authorAksu, Guzide
dc.contributor.authorCavusoglu, Cengiz
dc.contributor.authorKutukculer, Necil
dc.date.accessioned2019-10-27T11:05:50Z
dc.date.available2019-10-27T11:05:50Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Susceptibility to mycobacterial diseases is observed in some primary immunodeficiency diseases. In this study, we aimed to evaluate mycobacterial infections in primary immunodeficiency diseases. Material and Methods: Patients under follow-up by Ege University Pediatric Immunology Department for severe combined and combined immunodeficiencies, interleukin 12/interferon gamma receptor deficiency, nuclear factor kappa-beta essential modulator deficiency and chronic granulomatosis disease were evaluated retrospectively in terms of the frequency and characteristics of mycobacterial infections using a questionnaire form for demographic properties, clinical features and laboratory tests. Results: A diagnosis of mycobacterial infection was made clinically in a total of 25 patients including five (11.3%) of 45 patients who had severe combined immune deficiency, 12 (52.3%) of 21 patients who had chronic granulomatous disease, four patients (100%) who had interferon gamma receptor 2 partical deficiency, two patients (100%) who had interleukin 12 receptor beta 1 deficiency and one patient (100%) who had nuclear factor kapa-beta essential modulator deficiency. Mycobacterium strain could be typed in 14 (33%) of these 25 patients including Mycobacterium bovis, Mycobacterium chelonea, Mycobacterium elephantis, Mycobacterium fortuitum, and Mycobacterium tuberculosis. All patients were treated with anti-tuberculosis therapy. Thirty-six percent of these 25 patients underwent hematopoietic stem cell transplantation. Eight patients (five before, three after transplantation) died. Conclusions: Non-tuberculosis mycobacteria including mainly Mycobacterium bovis were observed with a higher rate compared to Mycobacterium tuberculosis in primary immunodeficiencies, especially in those affecting the interleukin 12/interferon gamma pathway. Early diagnosis of primary immunodeficiencies with neonatal screening program and preventing administration of the Bacille Calmette-Guerin vaccine in these patients is important.en_US
dc.identifier.doi10.5152/TurkPediatriArs.2017.5240en_US
dc.identifier.endpage144en_US
dc.identifier.issn1306-0015
dc.identifier.issn1308-6278
dc.identifier.issue3en_US
dc.identifier.pmid29062247en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage138en_US
dc.identifier.urihttps://doi.org/10.5152/TurkPediatriArs.2017.5240
dc.identifier.urihttps://hdl.handle.net/11454/31747
dc.identifier.volume52en_US
dc.identifier.wosWOS:000413141200005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurk Pediatri Arsivi-Turkish Archives of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBacille Calmette-Guerinen_US
dc.subjectinterleukin 12en_US
dc.subjectinterferon gammaen_US
dc.subjectmycobacteriaen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectprimary immunodeficiencyen_US
dc.titleFrequency of Mycobacterium bovis and mycobacteria in primary immunodeficienciesen_US
dc.typeArticleen_US

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