Effect of zinc sulfate on common cold in children: Randomized, double blind study

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dc.contributor.authorKurugol, Zafer
dc.contributor.authorBayram, Nuri
dc.contributor.authorAtik, Tahir
dc.date.accessioned2019-10-27T19:58:56Z
dc.date.available2019-10-27T19:58:56Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The aim of the present randomized, double-blind, placebo-controlled study was to determine the efficacy of zinc sulfate on the duration and severity of common cold in children. Methods: Children presenting at least two of 10 symptoms of common cold within the 24-48 h of the onset of illness were eligible for the study. Children were randomized to receive either oral zinc containing zinc sulfate or placebo. A diary was completed to record symptoms and adverse effects. Symptoms were scored as absent (0), mild (1), moderate (2), or severe (3). Results: One hundred and fifty children participated in the study, and 120 children were included in the final analysis. The median duration of all cold symptoms was 6 days (P = 0.20), and the median duration of nasal symptoms was 5 days in both groups (P = 0.09). However, total symptom severity scores were significantly lower in the zinc group, starting from the second day of the study. The lower scores in the zinc group were largely due to improvement of nasal symptom scores. Adverse effects were similar in both groups. Conclusion: Zinc sulfate had no effect on the duration of cold symptoms. However, it appears to be effective in reducing the severity of the cold symptoms in healthy children.en_US
dc.identifier.doi10.1111/j.1442-200X.2007.02448.xen_US
dc.identifier.endpage847en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue6en_US
dc.identifier.pmid18045283en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage842en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-200X.2007.02448.x
dc.identifier.urihttps://hdl.handle.net/11454/41128
dc.identifier.volume49en_US
dc.identifier.wosWOS:000251253100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjectcommon colden_US
dc.subjectzinc sulfateen_US
dc.titleEffect of zinc sulfate on common cold in children: Randomized, double blind studyen_US
dc.typeArticleen_US

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