Exopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicity

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dc.contributor.authorCeyhan Güvensen, Nur
dc.contributor.authorŞancı, Ebru
dc.contributor.authorYavaşoğlu, Nefise Ülkü Karabay
dc.contributor.authorTaşkaya, Aylin
dc.contributor.authorGüler, Cem
dc.date.accessioned2024-08-25T18:53:49Z
dc.date.available2024-08-25T18:53:49Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractMicrobial polysaccharides are extracellular polymeric macromolecules excreted in microorganisms. These are widely used in food, cosmetic and pharmaceutical industries. One of them, exopolysaccharides (EPS), plays important role against the factors such as phage attack, antibiotics, toxic compounds or osmotic stress. Recently, this natural polymer has received great attention due to their therapeutic potential. The purpose of the study was to evaluate biological activity and potential toxicity of EPS from Rhodococcus pyridinivorans ZZ47 strain isolated from nature. EPS has no genotoxic effect on Salmonella typhimurium TA98, TA102, and TA1537 strains by Ames Test. No death occurred with single dose oral toxicity test of EPS and LD50 value of it is calculated by >2000 mg/kg in mice. The EPS showed antibiofilm activity on different bacteria. In addition, EPS demonstrated dose-dependent anti-angiogenic properties by HET-CAM test. In conclusion, the isolated EPS has antioxidant activity with no genotoxicity and the biological activities of the polymer indicated that it may be suitable for use in different sectors and industrial applications.en_US
dc.identifier.doi10.56430/japro.1307611
dc.identifier.endpage71en_US
dc.identifier.issn2757-6620
dc.identifier.issue1en_US
dc.identifier.startpage63en_US
dc.identifier.trdizinid1185196en_US
dc.identifier.urihttps://doi.org/10.56430/japro.1307611
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1185196
dc.identifier.urihttps://hdl.handle.net/11454/103268
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of agricultural production (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.titleExopolysaccharide from Rhodococcus pyridinivorans ZZ47 Strain: Evaluation of Biological Activity and Toxicityen_US
dc.typeArticleen_US

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