Factors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patients

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dc.contributor.authorCelik, Gulperi
dc.contributor.authorDemirci, Meltem Sezis
dc.contributor.authorTumuklu, Murat
dc.contributor.authorAsci, Gulay
dc.contributor.authorSipahi, Savas
dc.contributor.authorToz, Huseyin
dc.contributor.authorBasci, Ali
dc.contributor.authorOk, Ercan
dc.date.accessioned2019-10-27T21:28:02Z
dc.date.available2019-10-27T21:28:02Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Augmentation index (AIx) and pulse wave velocity (PWV) are early markers of atherosclerotic vascular changes and also have been shown to be predictive of cardiovascular disease and total mortality. The aim of our study was to evaluate the relationship between PWV and AIx-HR75, which is the corrected form of AIx according to a heart rate of 75 beats/min, echocardiographic parameters and biochemical parameters in chronic hemodialysis (HD) patients. Subjects and methods: AIx-HR75 and PWV were measured in 556 HD patients by applanation tonometry using the SphygmoCor device. Results: The mean PWV and AIx-HR75 values of the study group were 10.2 +/- 2.4 and 28.4 +/- 10.2 m/s. A positive correlation was found between PWV and AIx-HR75 (r = 0.214, p = 0.000). AIx-HR75 correlated with age (r = 0.093, p = 0.028), body surface area (BSA) (r = -0.194, p = 0.000), mean arterial pressure (MAP) (r = 0.335, p = 0.000), pulse pressure (PP) (r = 0.212, p = 0.000), cardiothoracic index (r = 0.155, p = 0.016), and presence of left ventricular hypertrophy (r = 0.152, p = 0.001). PWV correlated with MAP (r = 0.208, p = 0.000), PP (r = 0.098, r = 0.021), left ventricular mass (r = 0.105, p = 0.023), and predialysis sodium level (r = -0.105, p = 0.023). In the multivariate analyses, PWV was associated with MAP (t = 3.78, p = 0.000), presence of diabetes (t = 3.20, p = 0.001), and predialysis sodium level (t = -2.06, p = 0.040), and AIx-HR75 was associated with age (t = 2.48, p = 0.014), female sex (t = 3.98, p = 0.000), BSA (t = -2.15, p = 0.033), and MAP (t = 7.02, p = 0.000). Conclusion: There is a strong association between MAP and arterial stiffness parameters in HD patients. We feel that efficient control of blood pressure could lead to reduced arterial stiffness in HD patients.en_US
dc.identifier.doi10.3109/0886022X.2011.615967en_US
dc.identifier.endpage963en_US
dc.identifier.issn0886-022X
dc.identifier.issue10en_US
dc.identifier.pmid21902600en_US
dc.identifier.startpage957en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2011.615967
dc.identifier.urihttps://hdl.handle.net/11454/45147
dc.identifier.volume33en_US
dc.identifier.wosWOS:000296091000006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthemodialysisen_US
dc.subjectaugmentation indexen_US
dc.subjectpulse wave velocityen_US
dc.subjectmean arterial blood pressureen_US
dc.subjectleft ventricular massen_US
dc.titleFactors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patientsen_US
dc.typeArticleen_US

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