Evaluation of cancer imaging potential and photodynamic therapy efficacy of copper (II) benzyloxypheophorbide-a

Basit Öğe Kaydı
dc.contributor.authorOcakoglu, Kasim
dc.contributor.authorEr, Ozge
dc.contributor.authorLambrecht, Fatma Yurt
dc.contributor.authorSusluer, Sunde Yilmaz
dc.contributor.authorKayabasi, Cagla
dc.contributor.authorGunduz, Cumhur
dc.contributor.authorYilmaz, Osman
dc.date.accessioned2019-10-27T22:30:41Z
dc.date.available2019-10-27T22:30:41Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractThe biological potential of a synthetic copper chlorophyll derivative was investigated via in vivo and in vitro experiments. The Cu-chlorophyll derivative photosensitizer (Cu-PH-A) was labeled with I-131 with high efficiency (92.9 +/- 4.2%) using the iodogen method. Cell culture studies were performed with the MCF-7 and MDAH-2774 cell lines after radiolabeling. The photosensitizing activity of Cu-PH-A was more effective in MDAH-2774 cells than in MCF-7 cells at a concentration of 50 mu M. When the biodistribution in female Albino Wistar rats was examined, uptake of the radiolabeled photosensitizer was maximal in the liver and ovaries after 60 min. It is concluded that radiolabeled Cu-chlorophyll derivative photosensitizer has high uptake in ovaries in normal rats. In addition, the intercellular uptake and PDT efficacy of the Cu-PH-A in MDAH-2774 were good compared with MCF-7 cells. This photosensitizer could be useful for both ovary tumour imaging and PDT.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey, TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T565]en_US
dc.description.sponsorshipThe authors declared no declaration of interest. The authors gratefully acknowledge financial support by The Scientific and Technological Research Council of Turkey, TUBITAK (Grant no: 112T565).en_US
dc.identifier.doi10.3109/1061186X.2014.958845en_US
dc.identifier.endpage95en_US
dc.identifier.issn1061-186X
dc.identifier.issn1029-2330
dc.identifier.issue1en_US
dc.identifier.pmid25230852en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.3109/1061186X.2014.958845
dc.identifier.urihttps://hdl.handle.net/11454/51264
dc.identifier.volume23en_US
dc.identifier.wosWOS:000346915600008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Drug Targetingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectI-131en_US
dc.subjectchlorophyll-aen_US
dc.subjectmetallo-chlorophyllen_US
dc.subjectnuclear imagingen_US
dc.subjectphotodynamic therapyen_US
dc.titleEvaluation of cancer imaging potential and photodynamic therapy efficacy of copper (II) benzyloxypheophorbide-aen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu