Design, Synthesis and Biological Evaluation of Novel Gypsogenin Derivatives as Potential Anticancer and Antimicrobial Agents

Basit Öğe Kaydı
dc.authoridEMİRDAĞ, SAFİYE/0000-0002-1676-2881
dc.authoridULUSOY, NAFIA GOKCE/0000-0001-6604-7838
dc.contributor.authorEmirdag, Safiye
dc.contributor.authorUlusoy, Nafia Gokce
dc.contributor.authorAksel, Mehran
dc.date.accessioned2024-08-31T07:49:21Z
dc.date.available2024-08-31T07:49:21Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractNatural compounds are important sources for the treatment of chronic disorders such as cancer and microbial infectious disorders. In this research, Gypsogenin and its derivatives (2 a-2 f) have been tested against different cancer cell lines (MCF-7, HeLa, Jurkat and K562 cell lines) and further analyzed for cell proliferation, cell death type, and for act of the mechanism. Cell proliferation was determined by the MTT method and cell death types were analyzed with HO/PI staining. Fibroblast Growth Factor 1 (FGF-1), Interleukin 1 (IL-1), Interleukin 6 (IL-6), and Tumor Necrosis Factor Alpha (TNF-alpha), key players in breast cancer development and progression, were determined by Elisa kits. Results showed that compound 2 e inhibited the MCF-7 cell line proliferation with an IC50 value of 0.66 +/- 0.17 mu M with 93.38 % apoptosis rate. Compound 2 e also decreased FGF-1, IL-1, IL-6, and TNF-alpha levels. Molecular docking studies performed in the binding site of FGFR-1 indicated that compound 2 e formed key hydrogen bonding with Arg627 and Asn568. Besides, compounds 2 a-2 f were evaluated for their antimicrobial activities against gram-negative and gram-positive bacteria and C. albicans via the microdilution method. Overall, compound 2 e stands out as a potential anticancer agent for future studies. imageen_US
dc.description.sponsorshipScientific Research Projects of Ege University [17FEN064]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects of Ege University (17FEN064). We are grateful to Professor Dr. Ali OEzmen and Research Associate Dr. OEmer Erdo & gbreve;an for biological activity studies. We also would like to thank to Dr. Belgin Sever for molecular docking studies.en_US
dc.identifier.doi10.1002/cbdv.202400471
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue6en_US
dc.identifier.pmid38594210en_US
dc.identifier.scopus2-s2.0-85192841676en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202400471
dc.identifier.urihttps://hdl.handle.net/11454/104816
dc.identifier.volume21en_US
dc.identifier.wosWOS:001218527500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectGypsogeninen_US
dc.subjectSemi-Synthesisen_US
dc.subjectApoptosisen_US
dc.subjectAnticancer Activityen_US
dc.subjectMolecular Dockingen_US
dc.titleDesign, Synthesis and Biological Evaluation of Novel Gypsogenin Derivatives as Potential Anticancer and Antimicrobial Agentsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu