Van der Knaap syndrome: MR imaging findings including FLAIR, diffusion imaging, and proton MR spectroscopy

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dc.contributor.authorSener R.N.
dc.date.accessioned2019-10-27T09:00:15Z
dc.date.available2019-10-27T09:00:15Z
dc.date.issued2000
dc.departmentEge Üniversitesien_US
dc.description.abstractA patient is reported with diffuse leukoen-cephalopathy associated with cystic degeneration of the white matter of the brain (van der Knaap syndrome). The changes were studied by fluid attenuated inversion recovery (FLAIR) and diffusion-weighted MR imaging. The FLAIR sequence revealed suppressed signal of the cysts, and widespread high-signal white matter changes associated with thinned cortices. On diffusion-weighted MR imaging, apparent diffusion coefficient (ADC) values ranged from 3.0 x 10-3 to 2.7 x 10-3 mm2/s in the temporal cysts, similar to that of CSF. The ADC values within the parenchyma ranged between 2 x 10-3 and 2.1 x 10-3 mm2/s, a value falling between normal parenchyma and cerebrospinal fluid, compared with a control group of three healthy subjects. The changes were also evaluated by proton MR spectroscopy, and were compared with a control group of 12 cases. Magnetic resonance spectroscopy revealed apparently increased NAA/Cr ratios in most parts of the brain. The NAA/Cho ratios were either high or low, and the Cho/Cr ratios were increased or normal in different regions.en_US
dc.identifier.doi10.1007/s003300000324en_US
dc.identifier.endpage1455en_US
dc.identifier.issn0938-7994
dc.identifier.issue9en_US
dc.identifier.pmid10997435en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1452en_US
dc.identifier.urihttps://doi.org/10.1007/s003300000324
dc.identifier.urihttps://hdl.handle.net/11454/28024
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAttenuated inversion recovery imagingen_US
dc.subjectInfantile-onset leukoencephalopathyen_US
dc.subjectMegalencephalyen_US
dc.subjectMR diffusion-weighted imagingen_US
dc.subjectMR fluiden_US
dc.subjectMR spectroscopyen_US
dc.subjectMR studiesen_US
dc.titleVan der Knaap syndrome: MR imaging findings including FLAIR, diffusion imaging, and proton MR spectroscopyen_US
dc.typeArticleen_US

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