Effect of chemotherapy on primordial follicular reserve of rat: An animal model of premature ovarian failure and infertility

Basit Öğe Kaydı
dc.contributor.authorYucebilgin, MS
dc.contributor.authorTerek, MC
dc.contributor.authorOzsaran, A
dc.contributor.authorAkercan, F
dc.contributor.authorZekioglu, O
dc.contributor.authorIsik, E
dc.contributor.authorErhan, Y
dc.date.accessioned2019-10-27T19:05:27Z
dc.date.available2019-10-27T19:05:27Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: To determine the effect of paclitaxel and cisplatin in the reduction of primordial follicular reserve in rat. Material and methods: Thirty young female rats were divided randomly into three groups of 10 rats each. Paclitaxel 7.5 mg/kg and cisplatin 5 mg/kg were administered intraperitoneally in a single dose sterile technique to paclitaxel (n = 10), and cisplatin (n =10) groups, and sterile saline solution was given to a control group (n = 10). To assess the effects of chemotherapeutic agents on the primordial follicles, the rats were oophorectomised 7 days after the administration of chemotherapeutic agents. Haematoxylin and eosin staining was used to determine the number of primordial follicles. Primordial follicles were identified by the presence of an oocyte encapsulated partially or completely by a single layer of flattened follicular cells without a theca layer at the ovarian cortex. Results: The number of primordial follicles in the control group was 23.1 +/- 16.1 follicles. The number of primordial follicles were decreased significantly in both paclitaxel and cisplatin groups compared to control group (10.3 +/- 13.0 and 13.9 +/- 15.2 follicles, respectively) (P = 0.001 and P = 0.01, respectively). The difference in the number of primordial follicles between the paclitaxel and cisplatin groups was insignificant (P = 0.465). Conclusion: The administration of high dose paclitaxel and cisplatin to young rats causes the depletion of primordial follicles. However, no significant difference was observed between the two agents.en_US
dc.identifier.doi10.1111/j.1479-828X.2004.00143.xen_US
dc.identifier.endpage9en_US
dc.identifier.issn0004-8666
dc.identifier.issn1479-828X
dc.identifier.issue1en_US
dc.identifier.pmid15089860en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.1111/j.1479-828X.2004.00143.x
dc.identifier.urihttps://hdl.handle.net/11454/38291
dc.identifier.volume44en_US
dc.identifier.wosWOS:000230814700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAustralian & New Zealand Journal of Obstetrics & Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchemotherapyen_US
dc.subjectcisplatinen_US
dc.subjectovarian failureen_US
dc.subjectpaclitaxelen_US
dc.subjectprimordial follicleen_US
dc.subjectraten_US
dc.titleEffect of chemotherapy on primordial follicular reserve of rat: An animal model of premature ovarian failure and infertilityen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu