Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA-PAA nano-encapsulation on PANC-1 pancreatic cancer cell line

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dc.contributor.authorJadid, Mahdieh Farhoudi Sefidan
dc.contributor.authorShademan, Behrouz
dc.contributor.authorChavoshi, Reza
dc.contributor.authorSeyyedsani, Nasrin
dc.contributor.authorAghaei, Elnaz
dc.contributor.authorTaheri, Elham
dc.contributor.authorSabet, Mehrdad Nasrollahzadeh
dc.date.accessioned2021-05-03T20:28:02Z
dc.date.available2021-05-03T20:28:02Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractMany chemotherapeutic regimens have been investigated for advanced unresectable and metastatic pancreatic cancer (PC), but with only minimal improvement in survival and prognosis. Here, we investigated anti-cancer function of free and nano-encapsulated hydroxytyrosol (Hyd) and curcumin (Cur), and its combinations (Hyd-Cur) on PANC-1 cell line. The poly lactide-co-glycolide-co-polyacrylic acid (PLGA-co-PAA) nano-encapsulated Hyd and Cur were synthesized, and MTT assay was performed to evaluate cytotoxic effects of free and nano-encapsulated Hyd, Cur, and Hyd-Cur. Effects of free and nano-encapsulated Hyd, Cur, and Hyd-Cur were evaluated on viability, migration, morphological alterations, colony formation, and apoptosis on PANC-1 cells. We observed that free and nano-encapsulated Hyd, Cur, and Hyd-Cur significantly increased apoptosis rates as well as significantly decreased viability, migration, and colony formation in PANC-1 cells. According to our results, Hyd-Cur combination and nano-encapsulation therapy exerts more profound apoptotic and anti-proliferative effects on PANC-1 cells than free Hyd or Hyd monotherapy.en_US
dc.identifier.doi10.1002/tox.23103en_US
dc.identifier.endpage1051en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue6en_US
dc.identifier.pmid33496383en_US
dc.identifier.scopus2-s2.0-85099960675en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1043en_US
dc.identifier.urihttps://doi.org/10.1002/tox.23103
dc.identifier.urihttps://hdl.handle.net/11454/69728
dc.identifier.volume36en_US
dc.identifier.wosWOS:000612051700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEnvironmental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectcurcuminen_US
dc.subjecthydroxytyrosolen_US
dc.subjectpancreatic canceren_US
dc.subjectPLGA-PAA copolymeren_US
dc.titleEnhanced anticancer potency of hydroxytyrosol and curcumin by PLGA-PAA nano-encapsulation on PANC-1 pancreatic cancer cell lineen_US
dc.typeArticleen_US

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