The relation of arterial stiffness with intrauterine growth retardation

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dc.contributor.authorLevent, Ertuerk
dc.contributor.authorAtik, Tahir
dc.contributor.authorDarcan, Suekran
dc.contributor.authorUlger, Zulal
dc.contributor.authorGoksen, Damla
dc.contributor.authorOzyurek, A. Ruhi
dc.date.accessioned2019-10-27T21:19:28Z
dc.date.available2019-10-27T21:19:28Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Much epidemiological evidence has linked low birthweight with late cardiovascular risk. Intrauterine growth retardation (IUGR) is associated with the increased risk of cardiovascular disease in adult life; it is unclear whether the relationship is present at younger ages. We evaluated whether abdominal aortic stiffness was altered in patients with IUGR (born at term with birthweight small for gestational age) in younger ages. Methods: Thirty-two (24 girls and eight boys) IUGR children aged 8.77 +/- 2.05 years were enrolled in the study. The birthweight was traced from the medical records. Their gestational ages were 38.9 +/- 0.85 weeks and birthweights 2130 +/- 198 g, respectively. Thirty-one healthy subjects who had normal gestational age and birthweight, matched for age and sex were recruited as a control group. Aortic strain, pressure strain elastic modulus (Ep), and normalized Ep and aortic distensibility were measured by a sphygmomanometer and transthoracic echocardiography in all subjects from the abdominal aorta. Results: There was no statistically significant difference between the study and the control groups in sex, mean age, body mass index, lipid profile, leptin, insulin-like growth factor-1 or insulin-like growth factor binding protein 3. In IUGR children, aortic strain (0.201 +/- 0.027 vs 0.254 +/- 0.031, P < 0.001) and aortic distensibility (1.08 +/- 0.19 vs 1.42 +/- 0.24, P < 0.001) were significantly lower compared with the control group. However Ep (188 +/- 36.2 vs 146 +/- 27.1, P < 0.001) and normalized Ep (2.97 +/- 0.40 vs 2.1 +/- 0.39, P < 0.001) were significantly higher in IUGR patients. Conclusions: This study demonstrates that abdominal aortic stiffness is increased in IUGR patients. These data suggest that prenatal events could be related to cardiovascular risk in later life.en_US
dc.identifier.doi10.1111/j.1442-200X.2009.02905.xen_US
dc.identifier.endpage811en_US
dc.identifier.issn1328-8067
dc.identifier.issue6en_US
dc.identifier.pmid19508453en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage807en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-200X.2009.02905.x
dc.identifier.urihttps://hdl.handle.net/11454/44150
dc.identifier.volume51en_US
dc.identifier.wosWOS:000271811000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishing, Incen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbirthweighten_US
dc.subjectcardiovascular risken_US
dc.subjectintrauterine growth retardationen_US
dc.subjectstiffness of abdominal aortaen_US
dc.subjectsubclinical atherosclerosisen_US
dc.titleThe relation of arterial stiffness with intrauterine growth retardationen_US
dc.typeArticleen_US

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