Broad-band ultraviolet B phototherapy is associated with elevated serum thiobarbituric acid reactive substance and nitrite-nitrate levels in psoriatic patients

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dc.contributor.authorKaraarslan, I. Kilinc
dc.contributor.authorSagin, F. Girgin
dc.contributor.authorErtam, I.
dc.contributor.authorAlper, S.
dc.contributor.authorOzturk, G.
dc.contributor.authorSozmen, E. Yildirim
dc.date.accessioned2019-10-27T19:40:38Z
dc.date.available2019-10-27T19:40:38Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Although the local anti-inflammatory, immunosuppressive and oxidative activity of UVB is known, the systemic effect of UVB phototherapy in dermatological patients has not been investigated. Objective We aimed to investigate the lipid peroxidation status (as represented by thiobarbituric acid reactive substance, TBARS) and nitrite-nitrate levels in psoriatic patients under broad-band ultraviolet B (BB-UVB) phototherapy in order to determine the systemic effects of UVB. Subjects and methods Thirty-two psoriatic patients and 20 healthy controls were included. Blood samples were obtained at the beginning, after 6-10 exposures to BB UVB phototherapy (mean 5 weeks) and at the end of the therapy period (mean 21 weeks). Serum TBARS and nitrite-nitrate levels were evaluated. Results There was no statistically significant difference in serum TBARS and nitrite-nitrate levels between psoriatic patients (basal) and healthy volunteers. There was no statistically significant correlation between disease duration, disease severity, or the total cumulative dose of UVB and serum levels of TBARS and nitrite-nitrate in psoriatic patients. Total nitrite levels in samples obtained during and at the end of therapy were significantly higher than basal levels (P = 0.033 and P = 0.005, respectively). TBARS levels in samples obtained during and at the end of therapy were significantly higher than basal levels (P = 0 and P = 0.026, respectively). There was a negative correlation (r = -0.576, P = 0.039) between the total nitrite and TBARS levels in psoriatic patients at the end of therapy. Conclusion Our study showed that chronic exposure to UV irradiation may lead to a systemic effect on lipid peroxidation and NO levels, which are shown by a significant elevation in TBARS and nitrite-nitrate levels in serum.en_US
dc.identifier.doi10.1111/j.1468-3083.2006.01765.xen_US
dc.identifier.endpage1231en_US
dc.identifier.issn0926-9959
dc.identifier.issn1468-3083
dc.identifier.issue10en_US
dc.identifier.pmid17062036en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1226en_US
dc.identifier.urihttps://doi.org/10.1111/j.1468-3083.2006.01765.x
dc.identifier.urihttps://hdl.handle.net/11454/40278
dc.identifier.volume20en_US
dc.identifier.wosWOS:000241502800009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of the European Academy of Dermatology and Venereologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbroad-band ultraviolet B phototherapyen_US
dc.subjectnitric oxideen_US
dc.subjectpsoriasisen_US
dc.subjectthiobarbituric acid reactive substanceen_US
dc.titleBroad-band ultraviolet B phototherapy is associated with elevated serum thiobarbituric acid reactive substance and nitrite-nitrate levels in psoriatic patientsen_US
dc.typeArticleen_US

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