Epstein-Barr virus (EBV) positive diffuse large B cell lymphoma of the elderly-Experience of a single center from Turkey

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dc.contributor.authorOzsan, Nazan
dc.contributor.authorCagirgan, Seckin
dc.contributor.authorSaydam, Güray
dc.contributor.authorGunes, Ajda
dc.contributor.authorHekimgil, Mine
dc.date.accessioned2019-10-27T21:42:43Z
dc.date.available2019-10-27T21:42:43Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the 2008 WHO lymphoma classification, 'EBV-positive diffuse large B cell lymphoma (DLBCL) of the elderly is included as a new provisional entity. We aimed to evaluate the morphological, immunophenotypic, and clinical characteristics of the cases diagnosed as 'EBV-positive DLBCL of the elderly' in our center and compared them with the 'EBV-negative DLBCL' patients older than 50 years of age. EBV status was detected by Epstein-Barr early RNA (EBER) in situ hybridization analysis. By immunohistochemistry, a panel of antibodies for CD10, Bcl-2, Bcl-6, IRF4/MUM1, CD30, and Ki67 was performed. Out of 149 DLBCL patients older than 50 years, without any known history of immunodeficiency or prior lymphoma, eight patients who fulfill the criteria were re-evaluated. Five patients were male and three were female, with a median age of 67.6 years. Four patients presented with nodal involvement; others presented with bone and soft tissue, bone marrow, and spleen infiltrations. Five cases revealed predominantly monomorphic morphology, one also contained focal areas consistent with polymorphous subtype; and three patients revealed a polymorphous infiltrate. When classified according to 'Hans criteria', five were non-GCB, and three were of the GCB cell phenotype. All cases with polymorphous morphology were revealed to be of the non-GCB cell phenotype, and all expressed IRF4/MUM1. Two patients died with disease, four patients are alive and in complete remission following R-CHOP therapy, and two patients have just recently been diagnosed. When compared with the EBV-negative group, there are no reliable morphological and immunohistochemical features indicating EBV positivity. Therefore, EBER in situ hybridization analysis is necessary to identify 'EBV-positive DLBCL of the elderly'. Further studies are needed to fully understand the details of this disease, which can lead to new treatment modalities. (C) 2013 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.prp.2013.04.014en_US
dc.identifier.endpage478en_US
dc.identifier.issn0344-0338
dc.identifier.issue8en_US
dc.identifier.pmid23726928en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage471en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2013.04.014
dc.identifier.urihttps://hdl.handle.net/11454/46952
dc.identifier.volume209en_US
dc.identifier.wosWOS:000324224900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofPathology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpstein-Barr virus EBVen_US
dc.subjectLarge B cell lymphomaen_US
dc.subjectSenescenceen_US
dc.subjectEpstein-Barr virus positive diffuse large B cell lymphoma of the elderlyen_US
dc.subjectEBERen_US
dc.titleEpstein-Barr virus (EBV) positive diffuse large B cell lymphoma of the elderly-Experience of a single center from Turkeyen_US
dc.typeArticleen_US

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