Mammillothalamic and Mammillotegmental Tracts as New Targets for Dementia and Epilepsy Treatment

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dc.contributor.authorBalak, Naci
dc.contributor.authorBalkuv, Ece
dc.contributor.authorKaradag, Ali
dc.contributor.authorBasaran, Recep
dc.contributor.authorBiceroglu, Huseyin
dc.contributor.authorErkan, Buruc
dc.contributor.authorTanriover, Necmettin
dc.date.accessioned2019-10-27T10:43:02Z
dc.date.available2019-10-27T10:43:02Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractBACKGROUND: Recently, neuromodulation through deep brain stimulation (DBS) has appeared as a new surgical procedure in the treatment of some types of dementia and epilepsy. The mammillothalamic and mammillotegmental tracts are involved among the new targets. To our knowledge, a review article focused specifically on these mammillary body efferents is lacking in the medical literature. Their contribution to memory is, regrettably, often overlooked. METHODS: A review of the relevant literature was conducted. RESULTS: There is evidence that mammillary bodies can contribute to memory independently from hippocampal formation, but the mechanism is not yet known. Recent studies in animals have provided evidence for the specific roles of these mammillary body efferents in regulating memory independently. In animal studies, it has been shown that the disruption of the mammillothalamic tract inhibits seizures and that electrical stimulation of the mammillary body or mammillothalamic tract raises the seizure threshold. In humans, DBS targeting the mammillary body through the mammillothalamic tract or the stimulation of the anterior thalamic nucleus, especially in the areas closely related to the mammillothalamic tract, has been found effective in patients with medically refractory epilepsy. Nonetheless, little knowledge exists on the functional anatomy of the mammillary body efferents, and their role in the exact mechanism of epileptogenic activity and in the memory function of the human brain. CONCLUSIONS: A comprehensive knowledge of the white matter anatomy of the mammillothalamic and mammillotegmental tracts is crucial since they have emerged as new DBS targets in the treatment of various disorders including dementia and epilepsy.en_US
dc.identifier.doi10.1016/j.wneu.2017.10.168en_US
dc.identifier.endpage144en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid29129763en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2017.10.168
dc.identifier.urihttps://hdl.handle.net/11454/30717
dc.identifier.volume110en_US
dc.identifier.wosWOS:000425856900164en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmnesiaen_US
dc.subjectBrainen_US
dc.subjectEpilepsyen_US
dc.subjectMammillary body efferentsen_US
dc.subjectMemoryen_US
dc.subjectNeuroanatomyen_US
dc.titleMammillothalamic and Mammillotegmental Tracts as New Targets for Dementia and Epilepsy Treatmenten_US
dc.typeReview Articleen_US

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