Brain-Derived Neurotrophic Factor Gene Va166Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sample

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dc.contributor.authorOzturk, Onder
dc.contributor.authorBasay, Burge Kabukcu
dc.contributor.authorBuber, Ahmet
dc.contributor.authorBasay, Omer
dc.contributor.authorAlacam, Huseyin
dc.contributor.authorBacanli, Ali
dc.contributor.authorYilmaz, Senay Gorucu
dc.contributor.authorErdal, Mehmet Emin
dc.contributor.authorHerken, Hasan
dc.contributor.authorErcan, Eyup Sabri
dc.date.accessioned2019-10-27T23:08:49Z
dc.date.available2019-10-27T23:08:49Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that negatively affects different areas of life. We aimed to evaluate the associations between the Va166Met polymorphism of brain-derived neurotrophic factor (BDNF) and ADHD and to assess the effect of the BDNF polymorphism on the neurocognitive profile and clinical symptomatology in ADHD. Methods Two hundred one ADHD cases and 99 typically developing subjects (TD) between the ages of 8 and 15 years were involved in the study. All subjects were evaluated using a complete neuropsychological battery, Child Behavior Checklist, the Teacher's Report Form (TRF) and the DSM-IV Disruptive Behavior Disorders Rating Scale-teacher and parent forms. Results The GG genotype was significantly more frequent in the patients with ADHD than in the TD controls, and the GG genotype was also significantly more frequent in the ADHD-combined (ADHD-C) subtype patients than in the TDs. However, there were no significant associations of the BDNF polymorphism with the ADHD subtypes or neurocognitive profiles of the patients. The teacher-assessed hyperactivity and inattention symptom count and the total score were higher, and the appropriately behaving subtest score of the TRF was lower in the GG genotypes than in the GA and AA (i.e., the A-containing) genotypes. Conclusion We found a positive association between the BDNF gene Va166Met polymorphism and ADHD, and this association was observed specifically in the ADHD-C subtype and not the ADHD-predominantly inattentive subtype. Our findings support that the Va166Met polymorphism of BDNF gene might be involved in the pathogenesis of ADHD. Furthermore Va166Met polymorphism of BDNF gene may be more closely associated with hyperactivity rather than inattention.en_US
dc.identifier.doi10.4306/pi.2016.13.5.518en_US
dc.identifier.endpage525en_US
dc.identifier.issn1738-3684
dc.identifier.issn1976-3026
dc.identifier.issue5en_US
dc.identifier.pmid27757130en_US
dc.identifier.startpage518en_US
dc.identifier.urihttps://doi.org/10.4306/pi.2016.13.5.518
dc.identifier.urihttps://hdl.handle.net/11454/52390
dc.identifier.volume13en_US
dc.identifier.wosWOS:000384842300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Neuropsychiatric Assocen_US
dc.relation.ispartofPsychiatry Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAttention-deficit hyperactivity disorderen_US
dc.subjectBrain-derived neurotrophic factoren_US
dc.subjectGene polymorphismen_US
dc.titleBrain-Derived Neurotrophic Factor Gene Va166Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sampleen_US
dc.typeArticleen_US

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