Effects of Restraint Stress and Nitric Oxide Synthase Inhibition on Learning and Strategy Preference in Young Adult Male Rats

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dc.contributor.authorDagdeviren, Melih
dc.contributor.authorDogan, Yusuf Hakan
dc.contributor.authorKanit, Lutfiye
dc.date.accessioned2019-10-27T21:55:58Z
dc.date.available2019-10-27T21:55:58Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the effects of restraint stress and nitric oxide synthase (NOS) inhibition by N omega Nitro-L-Arginine (LNA) on learning and strategy preference. Material and Methods: Rats were randomly divided into four groups (Saline, Saline+Stress, LNA, LNA+Stress). Stress was applied for one hour in glass cylinders during 13 days. One hour after this stress application, water maze experiments were started. Injections (saline 1 ml/kg or 50 mg/kg LNA) were given 10 minutes before each experiment. The platform was kept visible or hidden (on the 4th, 8th, 12th days) at the same position. On the 13th day the platform was located on the opposite quadrant. Results: Saline groups exhibited significantly better performances (F-(1.31)=174.038 p<0.05) at the beginning compared to the NOS inhibited groups. For initial hidden platform days; stress was determined as an impairment factor (F-(1.31)=5.190 p=0.012). At the end, acquisition occurred on both visible and hidden platform days for all groups. There was no significant strategy preference difference between the groups.Development of the stress and NOS inhibition impairments were seen, particularly at different periods of the acquisition. Conclusion: NOS inhibition did not worsen restraint stress-induced learning impairments in rats. Lack of effect may be explained by the antidepressive consequences of NOS inhibition.en_US
dc.description.sponsorshipCenter for Brain Research unit of Ege UniversityEge Universityen_US
dc.description.sponsorshipThis study was supported by the "Center for Brain Research" unit of Ege University. The authors are grateful to Jacki Gutenkunst Gozen; English instructor at Izmir University of Economics, for editing and correcting the manuscript.en_US
dc.identifier.doi10.5152/balkanmedj.2012.100en_US
dc.identifier.endpage380en_US
dc.identifier.issn2146-3123
dc.identifier.issue4en_US
dc.identifier.pmid25207037en_US
dc.identifier.startpage376en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2012.100
dc.identifier.urihttps://hdl.handle.net/11454/48298
dc.identifier.volume29en_US
dc.identifier.wosWOS:000315000900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAves Yayinciliken_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLearningen_US
dc.subjectNOS inhibitionen_US
dc.subjectrestraint stressen_US
dc.subjectstrategy preferenceen_US
dc.subjectwater mazeen_US
dc.titleEffects of Restraint Stress and Nitric Oxide Synthase Inhibition on Learning and Strategy Preference in Young Adult Male Ratsen_US
dc.typeArticleen_US

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