Markers of long-term exposure to organophosphorus pesticides in farmers who work in viniculture and tobacco production in Turkey

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dc.contributor.authorSoezmen, Buelent
dc.contributor.authorPeker, Sule
dc.contributor.authorKaya, Uemmuehan
dc.contributor.authorErkan, Mualla
dc.contributor.authorSoezmen, Eser Yildirim
dc.date.accessioned2019-10-27T19:39:31Z
dc.date.available2019-10-27T19:39:31Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThe first aim of this study was to evaluate the degree of organophosphorus ( OP) pesticides' exposure in viniculture and tobacco production workers via physical examination ( neurology and general health aspect) and analysis of paraoxonase ( PON1) and butyrylcholinesterase ( BuChE) activities. The second aim was to investigate if PON1 polymorphism plays any role in long-term OP exposure. A total of 93 farmers who work as applicators in agriculture were studied. The data were evaluated according to agricultural type, and although the total exposure time was similar in both areas, BuChE and PON1 activities of farmers who work in tobacco production were lower. Overall, BuChE and PON1 activities showed a depletion in the farmer group compared to age-matched controls. When the farmers were categorized according to the number of their symptoms, the BuChE activities of farmers who had two or more symptoms were found to be depleted ( n = 43, 2948 +/- 756) compared to farmers who had one or no symptoms ( n = 37, 3356 +/- 659). Allele frequencies of patients and controls for positions 55 and 192 were similar to Turkish population data and there was no association between the allele polymorphism and symptoms/signs of long-term exposure. Our results indicate that there is an important inhibition of PON1 activity in chronic OP poisoning, and this together with BuChE activity might well be used as a reliable index of chronic exposure to OP.en_US
dc.identifier.doi10.1080/15376510601094115en_US
dc.identifier.endpage384en_US
dc.identifier.issn1537-6516
dc.identifier.issn1537-6524
dc.identifier.issue7en_US
dc.identifier.pmid20020940en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.1080/15376510601094115
dc.identifier.urihttps://hdl.handle.net/11454/40175
dc.identifier.volume17en_US
dc.identifier.wosWOS:000249262300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofToxicology Mechanisms and Methodsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectorganophosphorus pesticideen_US
dc.subjectbutyryl cholinesteraseen_US
dc.subjectparaoxonaseen_US
dc.subjectparaoxonase genotypeen_US
dc.titleMarkers of long-term exposure to organophosphorus pesticides in farmers who work in viniculture and tobacco production in Turkeyen_US
dc.typeArticleen_US

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