Association of the brain-derived neurotrophic factor Val66Met polymorphism with hippocampus volumes in drug-free depressed patients

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dc.contributor.authorGonul, Ali Saffet
dc.contributor.authorKitis, Omer
dc.contributor.authorEker, M. Cagdas
dc.contributor.authorEker, Ozlem Donat
dc.contributor.authorOzan, Erol
dc.contributor.authorCoburn, Kerry
dc.date.accessioned2019-10-27T21:24:51Z
dc.date.available2019-10-27T21:24:51Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives. Val66Met BDNF gene polymorphism is shown to affect the function of mature BDNF and mature BDNF plays an important role in the hippocampal neurogenesis and neuronal survival. Methods. A relationship of Val66Met BDNF gene polymorphism and hippocampal volumes in 33 MDD patients and 40 healthy controls is investigated. Region of interest analysis was conducted on the images acquired via MRI. Results. Depressed patients had smaller left hippocampal volumes compared to healthy controls. The diagnosis of MDD was not significantly related to hippocampal volumes among Met carriers; however, among Val homozygotes depressed patients had significantly smaller left hippocampal volumes compared to controls. Although both right and left hippocampal volumes showed nearly significant correlation with the duration of illness, this correlation reached (negative) significant levels only in the right hippocampal volume of the Val homozygotes. Conclusions. Val homozygote genotype may serve as a vulnerability factor in MDD regarding hippocampal volume loss. This finding can be considered as a supportive evidence for the neurotrophic factor hypothesis of depression.en_US
dc.description.sponsorshipIhsan Dogramaci Foundation; Izmir Psychiatric Associationen_US
dc.description.sponsorshipThis study is a part of SoCAT Project supported by Ihsan Dogramaci Foundation and was partially supported by Huray Fidaner Research Award of Izmir Psychiatric Association to corresponding author (ASG); the organizations mentioned above had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.en_US
dc.identifier.doi10.3109/15622975.2010.507786en_US
dc.identifier.endpage118en_US
dc.identifier.issn1562-2975
dc.identifier.issn1814-1412
dc.identifier.issue2en_US
dc.identifier.pmid20726825en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage110en_US
dc.identifier.urihttps://doi.org/10.3109/15622975.2010.507786
dc.identifier.urihttps://hdl.handle.net/11454/44677
dc.identifier.volume12en_US
dc.identifier.wosWOS:000287741900004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofWorld Journal of Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssociation of the brain-derived neurotrophic factor Val66Met polymorphism with hippocampus volumes in drug-free depressed patientsen_US
dc.typeArticleen_US

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