Fullerene modified single-use electrodes as a convenient biosensor platform for electrochemical monitoring of drug-DNA interaction

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dc.authoridErdem, Arzum/0000-0002-4375-8386
dc.authorscopusid55845006300
dc.authorscopusid7004459748
dc.authorwosidErdem, Arzum/X-1925-2019
dc.contributor.authorEksin, Ece
dc.contributor.authorErdem, Arzum
dc.date.accessioned2023-01-12T20:12:46Z
dc.date.available2023-01-12T20:12:46Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractFullerene enriched disposable electrodes were developed and used as a biosensor platform for electrochemical monitoring of drug-DNA interaction. The surface of pencil graphite electrode (PGE) was modified with fullerene in order to enhance electrode surface for efficient dsDNA immobilization. The surface of fullerene modified PGEs (f-PGEs) was characterized using scanning electron microscopy (SEM), and electrochemical impedance spectroscopy (EIS). The behavior of dsDNA layer onto f-PGE surface was investigated by EIS measurements in Fe(CN6)(4/3-)-redox system. After optimization of several experimental parameters, the suitability of the constructed electrodes as a sensor platform for monitoring of drug-DNA interaction has been examined. The reproducibility of the biosensor was also tested in the presence of dsDNA immobilization. Consequently, the developed fullerene based biosensor offers suitable platform for the electrochemical analysis of drug-DNA interaction sensitively.en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipA.E. would like to express her gratitude to the Turkish Academy of Sciences (TUBA) as a Principal member for its partial support.en_US
dc.identifier.doi10.29228/jrp.197
dc.identifier.endpage1006en_US
dc.identifier.issn2630-6344
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85133939280en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage997en_US
dc.identifier.trdizinid535943en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.197
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/535943
dc.identifier.urihttps://hdl.handle.net/11454/78357
dc.identifier.volume26en_US
dc.identifier.wosWOS:000836312200027en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal Of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFullereneen_US
dc.subjectpencil graphite electrodesen_US
dc.subjectelectrochemical biosensoren_US
dc.subjectelectrochemical impedance spectroscopyen_US
dc.subjectdrug-DNA interactionen_US
dc.subjectImpedance Spectroscopyen_US
dc.subjectImpedimetric Detectionen_US
dc.subjectCarbon Nanotubeen_US
dc.subjectSensoren_US
dc.subjectDacarbazineen_US
dc.subjectCompositeen_US
dc.subjectSurfacesen_US
dc.subjectLumazineen_US
dc.subjectEnzymeen_US
dc.titleFullerene modified single-use electrodes as a convenient biosensor platform for electrochemical monitoring of drug-DNA interactionen_US
dc.typeArticleen_US

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