Decellularised extracellular matrix-based biomaterials for repair and regeneration of central nervous system

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dc.authoridYesil-Celiktas, Ozlem/0000-0003-4509-2212
dc.authorid, Burcu/0000-0002-7869-647X
dc.authorscopusid55260014400
dc.authorscopusid57204924916
dc.authorscopusid22837401200
dc.authorwosidYesil-Celiktas, Ozlem/AAI-5713-2020
dc.contributor.authorYaldiz, Burcu
dc.contributor.authorSaglam-Metiner, Pelin
dc.contributor.authorYesil-Celiktas, Ozlem
dc.date.accessioned2023-01-12T19:58:31Z
dc.date.available2023-01-12T19:58:31Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThe central nervous system (CNS), consisting of the brain and spinal cord, regulates the mind and functions of the organs. CNS diseases, leading to changes in neurological functions in corresponding sites and causing long-term disability, represent one of the major public health issues with significant clinical and economic burdens worldwide. In particular, the abnormal changes in the extracellular matrix under various disease conditions have been demonstrated as one of the main factors that can alter normal cell function and reduce the neuroregeneration potential in damaged tissue. Decellularised extracellular matrix (dECM)-based biomaterials have been recently utilised for CNS applications, closely mimicking the native tissue. dECM retains tissue-specific components, including proteoglycan as well as structural and functional proteins. Due to their unique composition, these biomaterials can stimulate sensitive repair mechanisms associated with CNS damages. Herein, we discuss the decellularisation of the brain and spinal cord as well as recellularisation of acellular matrix and the recent progress in the utilisation of brain and spinal cord dECM.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [119M578]; Research Fund of Ege University [FUA-2020-22187]en_US
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) under grant number 119M578 and Research Fund of Ege University as an International Research Cooperation Project under grant number FUA-2020-22187.en_US
dc.identifier.doi10.1017/erm.2021.22
dc.identifier.issn1462-3994
dc.identifier.pmid34994341en_US
dc.identifier.scopus2-s2.0-85123270551en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1017/erm.2021.22
dc.identifier.urihttps://hdl.handle.net/11454/76929
dc.identifier.volume23en_US
dc.identifier.wosWOS:000739861300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofExpert Reviews in Molecular Medicineen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain decellularisationen_US
dc.subjectcentral nervous systemen_US
dc.subjectextracellular matrixen_US
dc.subjectspinal cord decellularisationen_US
dc.subjectstem cellsen_US
dc.subjectSupercritical Carbon-Dioxideen_US
dc.subjectNonthermal Irreversible Electroporationen_US
dc.subjectMesenchymal Stem-Cellsen_US
dc.subjectSpinal-Corden_US
dc.subjectAcellular Scaffolden_US
dc.subjectBiologic Scaffoldsen_US
dc.subjectBrainen_US
dc.subjectHydrogelsen_US
dc.subjectTissuesen_US
dc.subjectStabilityen_US
dc.titleDecellularised extracellular matrix-based biomaterials for repair and regeneration of central nervous systemen_US
dc.typeReviewen_US

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