Cancer Stem Cell and Embryonic Development-Associated Molecules Contribute to Prognostic Significance in Ovarian Cancer

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dc.contributor.authorOktem, Gulperi
dc.contributor.authorSanci, Muzaffer
dc.contributor.authorBilir, Ayhan
dc.contributor.authorYildirim, Yusuf
dc.contributor.authorKececi, Sibel D.
dc.contributor.authorAyla, Sule
dc.contributor.authorInan, Sevinc
dc.date.accessioned2019-10-27T21:34:43Z
dc.date.available2019-10-27T21:34:43Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Embryonic molecules and cancer stem cell signaling resemble each other, and they organize cancer modality. We hypothesized that similar immunohistochemical expressions between tumor spheroids and patients' samples compared with clinical relevance would give an important clue in patients' prognosis. Methods: Immunohistochemical expression of c-kit, Notch1, Jagged1, and Delta1 in 50 cases of primary ovarian tumors (10 endometrioid, 10 serous, 10 mucinous adenocarcinoma, 10 borderline serous, and 10 borderline mucinous tumors) and MDAH-2774 spheroids were investigated. Results were compared in both spheroids and tumor samples with morphologic parameters (histological grade) and clinical data (age, stage, tumor size, and metastasis). Results: High c-kit and Notch1 immunoreactivity was shown in spheroids, but interestingly immunoreactivity of these molecules in tumor samples was different from patients' clinicopathological characteristics. In serous carcinoma, metastasis correlated with Notch1 immunoexpression; in mucinous carcinoma, Jagged1 immunohistochemistry correlated with grade, stage, and metastasis of tumor; in borderline serous and mucinous tumors, Jagged1 correlated with high grade. Moreover, Jagged1 correlated with stage and Notch1 with size in borderline mucinous tumor. Endometrioid carcinoma statistics showed that there was a correlation between age and Notch1 expression. Conclusion: Notch1, Jagged1, and Delta1 expressions might be useful markers for clinical prognosis of ovarian carcinomas; and Notch pathway, one of the most intensively studied putative therapeutic targets, may be a useful marker for cancer. Consequently, Jagged1 could be a marker for tumor grades and Notch1 as a marker for metastases.en_US
dc.identifier.doi10.1097/IGC.0b013e31823228b2en_US
dc.identifier.endpage29en_US
dc.identifier.issn1048-891X
dc.identifier.issue1en_US
dc.identifier.pmid22080880en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1097/IGC.0b013e31823228b2
dc.identifier.urihttps://hdl.handle.net/11454/45672
dc.identifier.volume22en_US
dc.identifier.wosWOS:000298628800006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofInternational Journal of Gynecological Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvarian cancer stem cellen_US
dc.subjectNotch pathwayen_US
dc.subjectc-kiten_US
dc.subjectMulticellular tumor spheroidsen_US
dc.titleCancer Stem Cell and Embryonic Development-Associated Molecules Contribute to Prognostic Significance in Ovarian Canceren_US
dc.typeArticleen_US

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