White matter alterations related to attention-deficit hyperactivity disorder and COMT val(158)met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)

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dc.contributor.authorBasay, Burge Kabukcu
dc.contributor.authorBuber, Ahmet
dc.contributor.authorBasay, Omer
dc.contributor.authorAlacam, Huseyin
dc.contributor.authorOzturk, Onder
dc.contributor.authorSuren, Serkan
dc.contributor.authorAy, Ozlem Izci
dc.contributor.authorAcikel, Cengizhan
dc.contributor.authorAgladioglu, Kadir
dc.contributor.authorErdal, Mehmet Emin
dc.contributor.authorErcan, Eyup Sabri
dc.contributor.authorHerken, Hasan
dc.date.accessioned2019-10-27T22:58:11Z
dc.date.available2019-10-27T22:58:11Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: In this article, the COMT gene val(158)met polymorphism and attention-deficit hyperactivity disorder (ADHD)-related differences in diffusion-tensor-imaging-measured white matter (WM) structure in children with ADHD and controls were investigated. Patients and methods: A total of 71 children diagnosed with ADHD and 24 controls aged 8-15 years were recruited. Using diffusion tensor imaging, COMT polymorphism and ADHD-related WM alterations were investigated, and any interaction effect between the COMT polymorphism and ADHD was also examined. The effects of age, sex, and estimated total IQ were controlled by multivariate analysis of covariance (MANCOVA). Results: First, an interaction between the COMT val(158)met polymorphism and ADHD in the right (R) cingulum (cingulate gyrus) (CGC) was found. According to this, valine (val) homozygote ADHD-diagnosed children had significantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) in the R-CGC than ADHD-diagnosed methionine (met) carriers, and val homozygote controls had higher FA and lower RD in the R-CGC than val homozygote ADHD patients. Second, met carriers had higher FA and axial diffusivity in the left (L)-uncinate fasciculus and lower RD in the L-posterior corona radiata and L-posterior thalamic radiation (include optic radiation) than the val homozygotes, independent of ADHD diagnosis. Third, children with ADHD had lower FA in the L-CGC and R-retrolenticular part of the internal capsule than the controls, independent of the COMT polymorphism. Conclusion: Significant differences reported here may be evidence that the COMT gene val(158)met polymorphism variants, as well as ADHD, could affect brain development. ADHD and the COMT polymorphism might be interactively affecting WM development in the R-CGC to alter the WM connectivity in children with val homozygote ADHD.en_US
dc.identifier.doi10.2147/NDT.S104450en_US
dc.identifier.endpage981en_US
dc.identifier.issn1178-2021
dc.identifier.pmid27143897en_US
dc.identifier.startpage969en_US
dc.identifier.urihttps://doi.org/10.2147/NDT.S104450
dc.identifier.urihttps://hdl.handle.net/11454/51467
dc.identifier.volume12en_US
dc.identifier.wosWOS:000374501400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofNeuropsychiatric Disease and Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectneuroimagingen_US
dc.subjectattention deficiten_US
dc.subjecthyperactivityen_US
dc.subjectcatechol-O-methyltransferaseen_US
dc.titleWhite matter alterations related to attention-deficit hyperactivity disorder and COMT val(158)met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)en_US
dc.typeArticleen_US

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