Cycloartane and oleanane-type glycosides from Astragalus pennatulus

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dc.contributor.authorUn, Rabia
dc.contributor.authorHoro, Ibrahim
dc.contributor.authorMasullo, Milena
dc.contributor.authorFalco, Antonia
dc.contributor.authorSenol, Serdar G.
dc.contributor.authorPiacente, Sonia
dc.contributor.authorAlankus-Cahskan, Ozgen
dc.date.accessioned2019-10-27T23:11:04Z
dc.date.available2019-10-27T23:11:04Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractFour new cycloartane and one new oleanane-type glycosides were isolated from Astragalus pennatulus along with five known cycloartane-type glycosides. The structures of the new compounds were established as 3-O-beta-Dxylopyranosyl-6-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta-trihydroxy-24-oxo-20(R),25-epoxycycloartane (1), 3-O-[beta-D-glucuronopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]-3 beta,16 beta,24 alpha-trihydroxy-20(R),25-epoxycycloartane (2), 3-O-[beta-D-glucuronopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]-3 beta,16 beta,25-trihydroxy-20(R),24(S)-epoxycycloartane (3), 3,25-di-O-beta-D-glucopyranosy1-6-O-p-D-xylopyranosyl-3 beta,6 alpha,16 beta,25-tetrahydroxy-20(R),24(S)-epoxycycloartane (4), 29-O-alpha-L-rhamnopyranosyl-abrisapogenol B (5) by 1D and 2D-NMR experiments along with ESIMS and HRMS analyses. The aglycone of compound 1, 3 beta,6 alpha,16 beta-trihydroxy-24-oxo-20(R),25-epoxycycloartane, is reported for the first time. The cytotoxic activity of the isolated compounds was evaluated against three cancer cell lines including A549 (human lung adenocarcinoma), A375 (human melanoma) and DeFew (human B lymphoma) cells. None of the tested compounds caused a significant reduction of the cell number. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109T425]; Ege University Research FoundationEge University [2011 Fen 056]en_US
dc.description.sponsorshipThe authors are grateful to TUBITAK (109T425), and also Ege University Research Foundation (2011 Fen 056) for financial support.en_US
dc.identifier.doi10.1016/j.fitote.2016.01.015en_US
dc.identifier.endpage260en_US
dc.identifier.issn0367-326X
dc.identifier.issn1873-6971
dc.identifier.pmid26804373en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage254en_US
dc.identifier.urihttps://doi.org/10.1016/j.fitote.2016.01.015
dc.identifier.urihttps://hdl.handle.net/11454/53012
dc.identifier.volume109en_US
dc.identifier.wosWOS:000372685400041en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofFitoterapiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAstragalus pennatulusen_US
dc.subjectFabaceaeen_US
dc.subjectCycloartane saponinsen_US
dc.subjectCyclocephalogeninen_US
dc.titleCycloartane and oleanane-type glycosides from Astragalus pennatulusen_US
dc.typeArticleen_US

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