Akciğer kanserli hastalarda serum anti-siklik sitrüline peptid antikor ile hastalık ilişkisi
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Dosyalar
Tarih
2017
Yazarlar
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Yayıncı
Ege Üniversitesi, Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
GİRİŞ VE AMAÇ: Akciğer Kanseri; akciğerlerde anormal hücrelerin kontrolsüz olarak çoğalması sonucunda ortaya çıkar. Sigara akciğer kanseri etiyolojisinde birinci sırada yer almaktadır. Akciğer kanserinin belirtileri; kanserin kendisine, metastaza veya kanser hücreleri tarafından salgılanan hormon benzeri bazı maddelere bağlı olabilir. Paraneoplastik sendromlar uzak bölgelerde gelişen invazyon, obstrüksiyon veya metastaz ile ilişkili olmayan bir grup semptom ve bulgudan ibaret olup, malign hastalığın erken teşhisinde yardımcı olabilir. Bu çalışma, akciğer kanseri olan hastalarda serum Anti-CCP (Anti-Siklik Sitrüline Peptid) antikor düzeyinin, hastalık tipi ve evresi ile olası bir ilişkisini ortaya koymak için amaçlanmıştır. GEREÇ VE YÖNTEM: Çalışmaya İç Hastalıkları, Tıbbi Onkoloji, Göğüs Hastalıkları ve Radyasyon Onkolojisi Bölümlerinde akciğer kanseri tanısı ile izlenen 50 hasta alındı. Hastaların rutin kontrolleri sırasında kırmızı tüplerde istenen kanlar laboratuvarda çalışıldıktan sonra imha edilmeden önce toplanıp -20 °C derecede muhafaza edildi. Kontrol grubu ise dahiliye polikliniğine çeşitli sağlık sorunları (Diyabetes Mellitus [DM], Hipertansiyon [HT] vb.) nedeniyle gelen benzer yaş ve cinsiyette hastalardan seçildi. Hasta ve kontrol grubunun kanları tamamlandıktan sonra, alınan kan örneklerinden ELISA yöntemi ile serum Anti-CCP düzeyi bakıldı. Tüm olgulara ait sigara hikayesi, alkol kullanımı, kimyasal maruziyet, önceki medikal durumlar (tip 2 DM, HT, KOAH [Kronik Obstrüktif Akciğer Hastalığı], astım, sarkoidoz, RA [Romatoid Artrit]) ve tümör hikayesi (tümör mevcudiyeti, kemoterapi, radyoterapi ve ailede malign hastalık öyküsü) sorgulandı. BULGULAR: Yaptığımız çalışmada akciğer kanseri hastalarının median yaşı 63 kontrol grubunun ise 68 idi. Hasta ve kontrol grubunun her ikiside de 40 erkek ve 10 kadın bulunuyordu. Akciğer kanserli hastaların 36'sında (%72) sigara öyküsü bulunuyordu 11 (%22) hastanın sigara ile ilgili öyküsüne ulaşılamadı. 1 (%2) hasta hiç sigara kullanmamıştı. Hasta grubunda küçük hücreli dışı akciğer kanseri (KHDAK) olan 38, küçük hücreli akciğer kanseri (KHAK) olan 11 hasta vardı. Bir hastada ise KHAK ve KHDAK'nin adenokanser alt tipinin birlikteliği saptandı. KHDAK hastalarından evre 4 olan 16 (%32), evre 3 olan 15 (%30), evre 2 olan 4 (%8), evre 1 olan 2 (%4) ve evresi bilinmeyen 2 (%4) hasta bulunuyordu. KHAK hastalarında ise 6 hasta (%12) yaygın, 5 hasta (%10) ise sınırlı evre grubunda yer aldı. Hastaların anti-CCP değerleri ile bu demografik verileri karşılaştırıldığında anlamlı bir sonuca ulaşılamadı. SONUÇ: Bizim sonuçlarımıza göre anti-CCP akciğer kanserinin tanısında ve takibinde kullanılabilecek bir işaret olarak saptanmadı. Ancak bazı çalışmalarda akciğer kanseri ile sitrülinlenme ile ilgili bazı işaretlerin anlamlı olarak yüksek bulunması nedeniyle anti-CCP ile yapılacak daha geniş, prospektif ve planlı çalışmalara ihtiyaç duyulmaktadır.
INTRODUCTION AND AIM: Lung cancer is uncontrolled proliferation of abnormal cells in the lungs. The symptoms of lung cancer may be due to; cancer itself, spread to distant organs or hormone-like substances secreted by cancer cells. Paraneoplastic syndromes are a group of symptoms and signs that are not associated with invasion, obstruction, or metastasis in the remote areas and may be helpful in the early detection of malignant disease. In this study, it was aimed to reveal a possible relationship between serum Anti-CCP antibody level and disease type and and stage in patients with lung cancer. MATERIALS AND METHODS: Fifty patients with lung cancer diagnosed in the Departments of Internal Medicine, Medical Oncology, Chest Diseases and Radiation Oncology were included in the study. During the routine control of the patients, the blood in red tubes was collected and stored at -20 ° C after being studied in the laboratory. The control group was selected from the patients of similar age and sex who were applied to the internal medicine polyclinic because of various health problems (DM, HT, etc.). After collection of the blood of the patient and the control group was completed, serum Anti-CCP level was measured by ELISA method. All cases were questioned for smoking history, alcohol use, chemical exposure, previous medical conditions (type 2 DM, HT, COPD, asthma, sarcoidosis, RA) and tumor history (tumor presence, chemotherapy, radiotherapy and family history of malignant disease). RESULTS: In our study, the median age of the lung cancer patients was 63 and the control group was 68. Both the patient and control group had 40 males and 10 females. 36 of lung cancer patients (72%) had a history of smoking, we couldn't reach 11 (22%) of lung cancer patient's smoking history. 1 (2%) patient never smoked. There were 38 patients with NSCLC and 11 patients with SCLC in the patient group. In one patient, the coexistence of the adenocancer subtype of SCLC and NSCLC was detected. In the patient group, 16 of patients with NSCLC were stage 4 (32%), 15 were stage 3 (30%), 4 were stage 2 (8%), 2 were stage 1 (4%), and 2 patient's stage wasn't known (4%). Six patients (12%) were widespread stage in SCLC patients and 5 patients (10%) were in the limited stage group. When the anti-CCP values of patients were compared with these demographic data, no significant result was obtained. CONCLUSION: According to our results, anti-CCP was not detected as a sign that could be used in the diagnosis and follow-up of lung cancer. However, in some studies, some signs of citrullination were found to be significantly associated with lung cancer. Therefore, there is a need for wider, prospective and planned work to be done with anti-CCP.
INTRODUCTION AND AIM: Lung cancer is uncontrolled proliferation of abnormal cells in the lungs. The symptoms of lung cancer may be due to; cancer itself, spread to distant organs or hormone-like substances secreted by cancer cells. Paraneoplastic syndromes are a group of symptoms and signs that are not associated with invasion, obstruction, or metastasis in the remote areas and may be helpful in the early detection of malignant disease. In this study, it was aimed to reveal a possible relationship between serum Anti-CCP antibody level and disease type and and stage in patients with lung cancer. MATERIALS AND METHODS: Fifty patients with lung cancer diagnosed in the Departments of Internal Medicine, Medical Oncology, Chest Diseases and Radiation Oncology were included in the study. During the routine control of the patients, the blood in red tubes was collected and stored at -20 ° C after being studied in the laboratory. The control group was selected from the patients of similar age and sex who were applied to the internal medicine polyclinic because of various health problems (DM, HT, etc.). After collection of the blood of the patient and the control group was completed, serum Anti-CCP level was measured by ELISA method. All cases were questioned for smoking history, alcohol use, chemical exposure, previous medical conditions (type 2 DM, HT, COPD, asthma, sarcoidosis, RA) and tumor history (tumor presence, chemotherapy, radiotherapy and family history of malignant disease). RESULTS: In our study, the median age of the lung cancer patients was 63 and the control group was 68. Both the patient and control group had 40 males and 10 females. 36 of lung cancer patients (72%) had a history of smoking, we couldn't reach 11 (22%) of lung cancer patient's smoking history. 1 (2%) patient never smoked. There were 38 patients with NSCLC and 11 patients with SCLC in the patient group. In one patient, the coexistence of the adenocancer subtype of SCLC and NSCLC was detected. In the patient group, 16 of patients with NSCLC were stage 4 (32%), 15 were stage 3 (30%), 4 were stage 2 (8%), 2 were stage 1 (4%), and 2 patient's stage wasn't known (4%). Six patients (12%) were widespread stage in SCLC patients and 5 patients (10%) were in the limited stage group. When the anti-CCP values of patients were compared with these demographic data, no significant result was obtained. CONCLUSION: According to our results, anti-CCP was not detected as a sign that could be used in the diagnosis and follow-up of lung cancer. However, in some studies, some signs of citrullination were found to be significantly associated with lung cancer. Therefore, there is a need for wider, prospective and planned work to be done with anti-CCP.
Açıklama
Anahtar Kelimeler
Akciğer Kanseri, Anti-CCP, Paraneoplastik Sendrom, Lung Cancer, Anti-CCP, Paraneoplastic Syndrome
