Effects of percutaneous transhepatic biliary drainage on renal function in patients with obstructive jaundice

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dc.contributor.authorParildar, Zuhal
dc.contributor.authorCinar, Celal
dc.contributor.authorBarutcuoglu, Burcu
dc.contributor.authorBasol, Gunes
dc.contributor.authorParildar, Mustafa
dc.date.accessioned2019-10-27T21:24:53Z
dc.date.available2019-10-27T21:24:53Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractPURPOSE We assessed the effects of percutaneous transhepatic biliary drainage on renal function in patients with obstructive jaundice using the estimated glomerular filtration rate (eGFR) and evaluated the factors associated with renal dysfunction. MATERIALS AND METHODS Between July 2007 and September 2009, 108 consecutive patients (69 men 39 women; median age, 59 years; range, 29-87 years) with obstructive jaundice (20 benign, 88 malignant) that were unsuitable for endoscopic retrograde cholangiopancreticography were evaluated at admission and at follow-up exams five and thirty days after percutaneous transhepatic biliary drainage. Two patients with suspected contrast-induced nephropathy were excluded. Renal function was assessed by measuring levels of urea, creatinine and electrolytes and evaluating the modification of diet in the renal disease formula for eGFR. RESULTS eGFR was <60 mL/min/1.73 m(2) before percutaneous transhepatic biliary drainage in 27 patients (25%) and increased significantly 30 days after percutaneous transhepatic biliary drainage (P = 0.008). In the malignant external drainage subgroup, there was a significant increase in eGFR on the fifth day after percutaneous transhepatic biliary drainage (P = 0.038). The procedure-related mortality rate was zero. Nine malignant patients (8.49%) died within thirty days due to underlying diseases. On the fifth day, eGFR was significantly lower in these patients than in surviving patients (P = 0.049), and bilirubin levels were significantly higher before the intervention than in surviving patients (P = 0.04). Multiple logistic regression analysis showed that serum direct bilirubin is a significant predictor of renal function (P. 0.049). CONCLUSION Obstructive jaundice is associated with renal dysfunction, and serum direct bilirubin is a significant predictor of renal function. Percutaneous transhepatic biliary drainage improves renal function and is crucial for prognosis of obstructive jaundice.en_US
dc.identifier.doi10.4261/1305-3825.DIR.3253-09.1en_US
dc.identifier.endpage79en_US
dc.identifier.issn1305-3825
dc.identifier.issn1305-3612
dc.identifier.issue1en_US
dc.identifier.pmid20690079en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.4261/1305-3825.DIR.3253-09.1
dc.identifier.urihttps://hdl.handle.net/11454/44689
dc.identifier.volume17en_US
dc.identifier.wosWOS:000287226600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofDiagnostic and Interventional Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectjaundice, obstructiveen_US
dc.subjectglomerular filtration rateen_US
dc.subjectrenal insufficiencyen_US
dc.subjectdrainageen_US
dc.titleEffects of percutaneous transhepatic biliary drainage on renal function in patients with obstructive jaundiceen_US
dc.typeArticleen_US

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