European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

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dc.contributor.authorEgea, Javier
dc.contributor.authorFabregat, Isabel
dc.contributor.authorFrapart, Yves M.
dc.contributor.authorGhezzi, Pietro
dc.contributor.authorGorlach, Agnes
dc.contributor.authorKietzmann, Thomas
dc.contributor.authorKubaichuk, Kateryna
dc.contributor.authorKnaus, Ulla G.
dc.contributor.authorLopez, Manuela G.
dc.contributor.authorOlaso-Gonzalez, Gloria
dc.contributor.authorPetry, Andreas
dc.contributor.authorSchulz, Rainer
dc.contributor.authorVinal, Jose
dc.contributor.authorWinyard, Paul
dc.contributor.authorAbbas, Kahina
dc.contributor.authorAdemowo, Opeyemi S.
dc.contributor.authorAfonso, Catarina B.
dc.contributor.authorAndreadou, Ioanna
dc.contributor.authorAntelmann, Haike
dc.contributor.authorAntunes, Fernando
dc.contributor.authorAslan, Mutay
dc.contributor.authorBachschmid, Markus M.
dc.contributor.authorBarbosa, Rui M.
dc.contributor.authorBelousov, Vsevolod
dc.contributor.authorBerndt, Carsten
dc.contributor.authorBernlohr, David
dc.contributor.authorBertran, Esther
dc.contributor.authorBindoli, Alberto
dc.contributor.authorBottari, Serge P.
dc.contributor.authorBrito, Paula M.
dc.contributor.authorCarrara, Guia
dc.contributor.authorCasas, Ana I.
dc.contributor.authorChatzi, Afroditi
dc.contributor.authorChondrogianni, Niki
dc.contributor.authorConrad, Marcus
dc.contributor.authorCooke, Marcus S.
dc.contributor.authorCosta, Joao G.
dc.contributor.authorCuadrado, Antonio
dc.contributor.authorDang, Pham My-Chan
dc.contributor.authorDe Smet, Barbara
dc.contributor.authorButuner, Bilge Debelec
dc.contributor.authorDias, Irundika H. K.
dc.contributor.authorDunn, Joe Dan
dc.contributor.authorEdson, Amanda J.
dc.contributor.authorEl Assar, Mariam
dc.contributor.authorEl-Benna, Jamel
dc.contributor.authorFerdinandy, Peter
dc.contributor.authorFernandes, Ana S.
dc.contributor.authorFladmark, Kari E.
dc.contributor.authorForstermann, Ulrich
dc.contributor.authorGiniatullin, Rashid
dc.contributor.authorGiricz, Zoltan
dc.contributor.authorGorbe, Aniko
dc.contributor.authorGriffiths, Helen
dc.contributor.authorHampl, Vaclav
dc.contributor.authorHanf, Alina
dc.contributor.authorHerget, Jan
dc.contributor.authorHernansanz-Agustin, Pablo
dc.contributor.authorHillion, Melanie
dc.contributor.authorHuang, Jingjing
dc.contributor.authorIlikay, Serap
dc.contributor.authorJansen-Durr, Pidder
dc.contributor.authorJaquet, Vincent
dc.contributor.authorJoles, Jaap A.
dc.contributor.authorKalyanaraman, Balaraman
dc.contributor.authorKaminskyy, Danylo
dc.contributor.authorKarbaschi, Mahsa
dc.contributor.authorKleanthous, Marina
dc.contributor.authorKlotz, Lars-Oliver
dc.contributor.authorKorac, Bato
dc.contributor.authorSami Korkmaz, Kemal
dc.contributor.authorKoziel, Rafal
dc.contributor.authorKracun, Damir
dc.contributor.authorKrause, Karl-Heinz
dc.contributor.authorKren, Vladimir
dc.contributor.authorKrieg, Thomas
dc.contributor.authorLaranjinha, Joao
dc.contributor.authorLazou, Antigone
dc.contributor.authorLi, Huige
dc.contributor.authorMartinez-Ruiz, Antonio
dc.contributor.authorMatsui, Reiko
dc.contributor.authorMcBean, Gethin J.
dc.contributor.authorMeredith, Stuart P.
dc.contributor.authorMessens, Joris
dc.contributor.authorMiguel, Veronica
dc.contributor.authorMikhed, Yuliya
dc.contributor.authorMilisav, Irina
dc.contributor.authorMilkovic, Lidija
dc.contributor.authorMiranda-Vizuete, Antonio
dc.contributor.authorMojovic, Milos
dc.contributor.authorMonsalve, Maria
dc.contributor.authorMouthuy, Pierre-Alexis
dc.contributor.authorMulvey, John
dc.contributor.authorMunzel, Thomas
dc.contributor.authorMuzykantov, Vladimir
dc.contributor.authorNguyen, Isabel T. N.
dc.contributor.authorOelze, Matthias
dc.contributor.authorOliveira, Nuno G.
dc.contributor.authorPalmeira, Carlos M.
dc.contributor.authorPapaevgeniou, Nikoletta
dc.contributor.authorPavicevic, Aleksandra
dc.contributor.authorPedre, Brandan
dc.contributor.authorPeyrot, Fabienne
dc.contributor.authorPhylactides, Marios
dc.contributor.authorPircalabioru, Gratiela G.
dc.contributor.authorPitt, Andrew R.
dc.contributor.authorPoulsen, Henrik E.
dc.contributor.authorPrieto, Ignacio
dc.contributor.authorPia Rigobello, Maria
dc.contributor.authorRobledinos-Anton, Natalia
dc.contributor.authorRodriguez-Manas, Leocadio
dc.contributor.authorRolo, Anabela P.
dc.contributor.authorRousset, Francis
dc.contributor.authorRuskovska, Tatjana
dc.contributor.authorSaraiva, Nuno
dc.contributor.authorSasson, Shlomo
dc.contributor.authorSchroeder, Katrin
dc.contributor.authorSemen, Khrystyna
dc.contributor.authorSeredenina, Tamara
dc.contributor.authorShakirzyanova, Anastasia
dc.contributor.authorSmith, Geoffrey L.
dc.contributor.authorSoldati, Thierry
dc.contributor.authorSousa, Bebiana C.
dc.contributor.authorSpickett, Corinne M.
dc.contributor.authorStancic, Ana
dc.contributor.authorStasia, Marie Jose
dc.contributor.authorSteinbrenner, Holger
dc.contributor.authorStepanic, Visnja
dc.contributor.authorSteven, Sebastian
dc.contributor.authorTokatlidis, Kostas
dc.contributor.authorTuncay, Erkan
dc.contributor.authorTuran, Belma
dc.contributor.authorUrsini, Fulvio
dc.contributor.authorVacek, Jan
dc.contributor.authorVajnerova, Olga
dc.contributor.authorValentova, Katerina
dc.contributor.authorVan Breusegem, Frank
dc.contributor.authorVarisli, Lokman
dc.contributor.authorVeal, Elizabeth A.
dc.contributor.authorYalcin, A. Suha
dc.contributor.authorYelisyeyeva, Olha
dc.contributor.authorZarkovic, Neven
dc.contributor.authorZatloukalova, Martina
dc.contributor.authorZielonka, Jacek
dc.contributor.authorTouyz, Rhian M.
dc.contributor.authorPapapetropoulos, Andreas
dc.contributor.authorGrune, Tilman
dc.contributor.authorLamas, Santiago
dc.contributor.authorSchmidt, Harald H. H. W.
dc.contributor.authorDi Lisa, Fabio
dc.contributor.authorDaiber, Andreas
dc.date.accessioned2019-10-27T11:05:24Z
dc.date.available2019-10-27T11:05:24Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.en_US
dc.description.sponsorshipEuropean Cooperation in Science and Technology (COST)European Cooperation in Science and Technology (COST) [BM1203]; COST ActionsEuropean Cooperation in Science and Technology (COST) [BM1005, BM1307]; European CommissionEuropean Commission Joint Research Centreen_US
dc.description.sponsorshipThe EU-ROS consortium (COST Action BM1203) was supported by the European Cooperation in Science and Technology (COST). The present overview represents the final Action dissemination summarizing the major achievements of COST Action BM1203 (EU-ROS) as well as research news and personal views of its members. Some authors were also supported by COST Actions BM1005 (ENOG) and BM1307 (PROTEOSTASIS), as well as funding from the European Commission FP7 and H2020 programmes, and several national funding agencies.en_US
dc.identifier.doi10.1016/j.redox.2017.05.007en_US
dc.identifier.endpage162en_US
dc.identifier.issn2213-2317
dc.identifier.pmid28577489en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage94en_US
dc.identifier.urihttps://doi.org/10.1016/j.redox.2017.05.007
dc.identifier.urihttps://hdl.handle.net/11454/31670
dc.identifier.volume13en_US
dc.identifier.wosWOS:000410470000009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofRedox Biologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectReactive nitrogen speciesen_US
dc.subjectRedox signalingen_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidantsen_US
dc.subjectRedox therapeuticsen_US
dc.titleEuropean contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)en_US
dc.typeReview Articleen_US

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