Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents

Basit Öğe Kaydı
dc.authorwosidKOSE, Timur/ABH-3197-2021
dc.contributor.authorTekgul, Hasan
dc.contributor.authorSaz, Ulas
dc.contributor.authorPolat, Muzaffer
dc.contributor.authorTekgul, Nurdan
dc.contributor.authorKose, Timur
dc.date.accessioned2023-01-12T20:16:25Z
dc.date.available2023-01-12T20:16:25Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractContext: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to healthy developing children and adolescents. Settings and Design: In this cross-sectional study, we measured TMS evoked parameters associated with cortical and spinal stimulation obtained from the four extremities of 46 healthy children and adolescents (21 boys and 25 girls; mean +/- standard deviation age: 6.4 +/- 1.2 years; range: 3.0-20.5 years). Statistical Analysis: Spearman's correlation coefficients were calculated for each variable (weight and height) as a function of motor evoked potential (MEP) response latency and central motor conduction time (CMCT). Pearson's Chi-square test was used to determine the inter-variable correlations. Results: Latencies of MEPs were correlated with age (P < 0.001, r = 0.6948) and height (P < 0.006, r = 0.7994). Amplitudes of active-state MEPs were significantly higher than those of resting-state MEPs associated with the upper and lower extremities. The mean values for active-state MEP latencies were lower than those for resting-state MEPs. The CMCT and magnitudes of latency jumps were calculated using reliable MEP data for children and adolescents. Additionally, the unresponsiveness rates were significantly higher for children aged below 7 years. Conclusion: The TMS evoked parameters investigated in this study are necessary to accurately assess corticospinal pathway development in healthy children and adolescents.en_US
dc.identifier.doi10.4103/NSN.NSN_94_20
dc.identifier.endpage96en_US
dc.identifier.issn2636-865X
dc.identifier.issue2en_US
dc.identifier.startpage90en_US
dc.identifier.trdizinid509787en_US
dc.identifier.urihttps://doi.org/10.4103/NSN.NSN_94_20
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/509787
dc.identifier.urihttps://hdl.handle.net/11454/78710
dc.identifier.volume38en_US
dc.identifier.wosWOS:000668748900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNeurological Sciences And Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectiCentral motor conduction timeen_US
dc.subjectcorticospinal pathwaysen_US
dc.subjectlatency jumpingen_US
dc.subjectmotor evoked potentialsen_US
dc.subjecttranscranial magnetic stimulationen_US
dc.subjectCentral Motor Reorganizationen_US
dc.subjectPotentialsen_US
dc.subjectCortexen_US
dc.subjectMaturationen_US
dc.subjectPlasticityen_US
dc.subjectMechanismsen_US
dc.subjectPathwaysen_US
dc.subjectRootsen_US
dc.titleNormative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescentsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu