Post-stroke aggressive behavior in patients wıth first-ever ischemic stroke: underlying clinical and imaging factors

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dc.authorscopusid7003717249
dc.authorscopusid57223616502
dc.authorscopusid57201367527
dc.authorscopusid57191591918
dc.authorscopusid58488175300
dc.contributor.authorKumral, E.
dc.contributor.authorÇetin, F.E.
dc.contributor.authorÖzdemir, H.N.
dc.contributor.authorÇelikay, H.
dc.contributor.authorÖzkan, S.
dc.date.accessioned2024-08-25T18:35:51Z
dc.date.available2024-08-25T18:35:51Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Aggression is defined as a complex behavior consisting of a combination of sensory, emotional, cognitive and motor elements. We aimed to examine the relationships between post-stroke aggressive behavior (PSAB) and neuropsychological and neuroimaging findings. Methods: 380 patients in the stroke unit were classified as aggressive or non-aggressive based on symptoms elicited by the Neuropsychiatric Inventory (NPI) and aggression screening questionnaire. Results: Aggressive behavior was detected in 42 (11.1%) of 380 patients who had a first ischemic stroke. Patients with PSAB were older than those without (338 patients) (66.98 + 13.68 vs. 62.61 + 13.06, P = 0.043). Hamilton depression and anxiety scales showed significantly higher rates of depression and anxiety in the PSAB group compared to the non-PSAB group (47.6% vs. 16.3% and 57.1% vs. 15.4%, respectively; P = 0.001). Lesion mapping analysis showed that lesions in patients with PSAB mostly included the lower parietal lobe and lateral frontal gyrus. Multiple regression analysis showed that gender (OR, 2.81; CI%, 1.24–6.39), lateral prefrontal infarction (OR, 6.43; CI%, 1.51–27.44), parietal infarction (OR, 2.98; CI%, 1.15–7.76), occipital infarction (OR, 2.84; CI%, 1.00–8.06), multiple infarcts (OR, 5.62; CI%, 2.27–13.93), anxiety (OR, 2.06; CI%, 0.89–4.81) and verbal memory deficit (OR, 4.21; CI%, 1.37–12.93) were significant independent predictors of PSAB. Conclusion: The presence of PSAB may be related to neuropsychiatric symptoms such as high anxiety and verbal memory impairment, and neuroanatomical location of the lesions. © 2023, The Author(s) under exclusive licence to Belgian Neurological Society.en_US
dc.identifier.doi10.1007/s13760-023-02319-6
dc.identifier.issn0300-9009
dc.identifier.pmid37442871en_US
dc.identifier.scopus2-s2.0-85164769153en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s13760-023-02319-6
dc.identifier.urihttps://hdl.handle.net/11454/100446
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofActa Neurologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAggressionen_US
dc.subjectBehavioren_US
dc.subjectStrokeen_US
dc.titlePost-stroke aggressive behavior in patients wıth first-ever ischemic stroke: underlying clinical and imaging factorsen_US
dc.typeArticleen_US

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