Increased serum neopterin levels in women with polycystic ovary syndrome

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dc.contributor.authorBarutcuoglu, Burcu
dc.contributor.authorBozdemir, A. Erkin
dc.contributor.authorDereli, Didem
dc.contributor.authorParildar, Zuhal
dc.contributor.authorMutaf, M. Isil
dc.contributor.authorOzmen, Dilek
dc.contributor.authorBayindir, Oya
dc.date.accessioned2019-10-27T19:18:14Z
dc.date.available2019-10-27T19:18:14Z
dc.date.issued2006
dc.departmentEge Üniversitesien_US
dc.description.abstractPolycystic ovary syndrome (PCOS) occurs in 5-10% of premenopausal women. Studies suggest that PCOS is associated with increased risk of coronary heart disease (CHD). To investigate this relationship, 15 PCOS women (group 1) and 10 healthy women (group 2) were studied. Blood leukocyte counts (white blood cells, WBC) and serum levels of total cholesterol, HDL-cholesterol, LDL-cholesterol, sensitive C-reactive protein (sCRP), and neopterin were measured in the 2 groups. There were no significant differences in serum total cholesterol, HDL-cholesterol, or LDL-cholesterol concentrations between groups 1 and 2. Blood WBC counts and serum levels of neopterin and sCRP were significantly higher in group I than group 2. The median (min-max) levels were: WBC, group 1: 8.05 (5.10-9.70) cells x 10(9)/L, group 2: 6.25 (4.70-9.70) cells x 109/L (p < 0.01); neopterin, group 1: 10.6 (7.5-49.5) nmol/L, group 2: 9.6 (6.5-12.9) nmol/L (p < 0.05); and sCRP, group 1: 7.0 (1.2-12.0) mg/L, group 2: 2.0 (0.1-12.0) mg/L (p < 0.01). This study shows that blood WBC counts and serum sCRP and neopterin levels are significantly elevated in women with PCOS. These findings support an increased risk for early-onset cardiovascular disease in women with PCOS. This is the first report that women with PCOS have higher serum neopterin levels than healthy women with regular menstrual cycles.en_US
dc.identifier.endpage272en_US
dc.identifier.issn0091-7370
dc.identifier.issue3en_US
dc.identifier.pmid16951267en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://hdl.handle.net/11454/38548
dc.identifier.volume36en_US
dc.identifier.wosWOS:000240286000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssn Clinical Scientistsen_US
dc.relation.ispartofAnnals of Clinical and Laboratory Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectneopterinen_US
dc.subjectC-reactive proteinen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectWBC counten_US
dc.titleIncreased serum neopterin levels in women with polycystic ovary syndromeen_US
dc.typeArticleen_US

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