Long-term ongoing coagulopathy in premature infants with respiratory distress syndrome

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dc.contributor.authorBuyukinan M.
dc.contributor.authorYilmaz D.
dc.contributor.authorYalaz M.
dc.contributor.authorKoroglu O.A.
dc.contributor.authorAkisu M.
dc.contributor.authorKavakli K.
dc.contributor.authorKultursay N.
dc.date.accessioned2019-10-27T08:23:19Z
dc.date.available2019-10-27T08:23:19Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractThe previously reported activated intravascular coagulation system in the acute phase of respiratory distress syndrome (RDS) has not been evaluated in the long term. We assessed the activities of coagulation system of a cohort of premature infants with RDS in comparison with healthy premature infants (HPIs), healthy mature infants (HMIs), and pediatric laboratory controls over a 6-month period. Cord and venous blood samples were taken at birth, at the first month and sixth month. Protein C (PC), free protein S (f-PS), and antithrombin (AT) activities, thrombin-antithrombin (TAT) complex, prothrombin fragment 1 + 2 (PF1 + 2), and fibrinogen levels were measured. Mean PC, f-PS, d-dimer, and fibrinogen values were similar at all periods for HPI and RDS groups. Low neonatal anticoagulant proteins increased within 6 months in HMI and HPI groups. However, in RDS group, the AT activity remained significantly lower together with significantly higher TAT and PF1 + 2 levels both at the first month and at sixth month, suggesting a long-term consumption coagulopathy. © 2013 The Author(s).en_US
dc.identifier.doi10.1177/1076029612444003en_US
dc.identifier.endpage540en_US
dc.identifier.issn1076-0296
dc.identifier.issue5en_US
dc.identifier.pmid22556372en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage535en_US
dc.identifier.urihttps://doi.org/10.1177/1076029612444003
dc.identifier.urihttps://hdl.handle.net/11454/26407
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofClinical and Applied Thrombosis/Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectblood coagulation factorsen_US
dc.subjectconsumption coagulopathyen_US
dc.subjectnewbornen_US
dc.subjectrespiratory distress syndromeen_US
dc.titleLong-term ongoing coagulopathy in premature infants with respiratory distress syndromeen_US
dc.typeArticleen_US

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