Synthesis, radiolabeling and in vivo tissue distribution of an anti-oestrogen glucuronide compound, 99mTc-TOR-G
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Toremifene (TOR) has been used as an anti-oestrogen drug for the treatment and prevention of human breast cancer. The aim of this study was the addition of the hydrophilic groups diethylenetriamine pentaacetic acid (DTPA) and glucuronic acid to the starting substance TOR and to label it with technetium-99m (99mTc) radionuclide and to investigate radiopharmaceutical potential of the new compound. The synthesis reactions are completed in four steps, including enzymatic reaction, with the following substeps; preparation of microsomal fraction from Hutu 80 cell line and subsequent purification of UDP-glucuronyl transferase (UDPGT), estimation of protein quantity in microsomal samples and glucuronidation reaction. The results indicate that 99mTc-TOR-G may be proposed as a new anti-oestrogen glucuronide imaging agent for ovarian tumours.
Açıklama
Anahtar Kelimeler
99mTc-TOR-G, Diethylenetriamine pentaacetic acid DTPA, Receptor saturated study of toremifene-glucuronide- labelled with 99mTc 99mTc-Rec-TOR-G, Toremifene, Toremifene-glucuronide-labelled with 99mTc
Kaynak
Anticancer Research
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
30
Sayı
4
