Can daily bathing with 4% chlorhexidine plus daily chlorhexidine wipe for 1 week be effective in decolonizing Candida auris colonization?

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dc.authoridElbahr, Umran Sumeyse/0000-0001-6493-197X
dc.authorscopusid57907419900
dc.authorscopusid57983264300
dc.authorscopusid56580399700
dc.authorscopusid58726610100
dc.authorscopusid58726610200
dc.authorscopusid58728604500
dc.authorscopusid58727813700
dc.contributor.authorElbahr, Umran
dc.contributor.authorKhairy, Amira
dc.contributor.authorDayyab, Farouq
dc.contributor.authorDelos Reyes, Clark Steven
dc.contributor.authorPastrana, Jennie
dc.contributor.authorVineeth, Chithra
dc.contributor.authorHejres, Suha
dc.date.accessioned2024-08-25T18:36:54Z
dc.date.available2024-08-25T18:36:54Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Herein, it is aimed to present the decolonizing rates of Candida auris colonized cases after daily bathing with 4% chlorhexidine plus daily cleaning with 4% chlorhexidine wipe for 1 week (will be mentioned as DCHX).Methods The study period was from October, 2021, to November, 2022. Inclusion criteria were (i) age > 18, (ii) receiving DCHX, (iii) proven C. auris carrier on auricular, or axillar or inguinal swab surveillance cultures up to 5-day period before DCHX. Cases with three consecutive negative surveillance cultures 3 days apart were considered to be decolonized.Results A total of 38 cases [14 female, aged 61.8 +/- 15.5 years] fulfilled the inclusion criteria. Six (15.8%), 23 (60.1%), and 22 cases (57.8%) were postauricular, inguinal, and axillary culture positive, respectively. Only three cases (7.9%) were triple culture positive. Nine cases (23.7%) had three consequent negative surveillance cultures after DCHX and were considered to be decolonized. There was no significant difference in decolonization rates of concomitant only antibiotic receiving cohort vs. concomitant antifungal + antibiotic receiving cohort (5/16 vs. 2/8, p = 1) were decolonized similarly. Of the nine C. auris decolonized cases, two developed C. auris infection in 30 days follow-up after decolonization. However, 10 (34.5%) of 29 non-decolonized cases developed C. auris infection (p: 0.450) within 30 days after surveillance culture positivity. Over all cohorts, day 30 mortality was 23.7% (9/38).Conclusion In conclusion, based on our observational and relatively small uncontrolled series, it appears that DCHX is not very effective in decolonizing C. auris carriers (especially in cases who are C. auris colonized in > 1 areas), although it is not completely ineffective.en_US
dc.identifier.doi10.1007/s10096-023-04723-5
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.pmid38012351en_US
dc.identifier.scopus2-s2.0-85178090406en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-023-04723-5
dc.identifier.urihttps://hdl.handle.net/11454/100794
dc.identifier.wosWOS:001108624400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectCandida aurisen_US
dc.subjectColonizationen_US
dc.subjectDecolonizationen_US
dc.subjectChlorhexidineen_US
dc.subjectDisinfectantsen_US
dc.titleCan daily bathing with 4% chlorhexidine plus daily chlorhexidine wipe for 1 week be effective in decolonizing Candida auris colonization?en_US
dc.typeArticleen_US

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