Serum nitric oxide metabolites in patients with multiple sclerosis

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dc.contributor.authorNazliel, B
dc.contributor.authorTaskiran, D
dc.contributor.authorIrkec, C
dc.contributor.authorKutay, FZ
dc.contributor.authorPogun, S
dc.date.accessioned2019-10-27T18:43:52Z
dc.date.available2019-10-27T18:43:52Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractMultiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by myelin breakdown. The free radical nitric oxide (NO), which is considered to be a major metabolite in immune function and in autoimmune disorders, is among the possible mediators causing the inflammatory reactions in MS. Consequently, NO has been implicated in the pathogenesis of MS and its animal model experimental allergic encephalomyelitis (EAE). In this study, stable metabolites of NO (NO2-+NO3-) levels were determined in sera of MS patients (n=23) and control subjects (n=16). NO2-+NO3- levels were higher in MS patients when compared to control subjects. However, there was not any correlation with serum NO2-+NO3- values and clinical features of the disease such as duration of sickness, the time elapsed from the last attack and EDSS values. Our results imply that nitric oxide may be involved in the pathogenesis of MS although further studies are required to elucidate underlying mechanisms. (C) 2002 Published by Elsevier Science Ltd.en_US
dc.identifier.doi10.1054/jocn.2001.1077en_US
dc.identifier.endpage532en_US
dc.identifier.issn0967-5868
dc.identifier.issue5en_US
dc.identifier.pmid12383409en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage530en_US
dc.identifier.urihttps://doi.org/10.1054/jocn.2001.1077
dc.identifier.urihttps://hdl.handle.net/11454/37256
dc.identifier.volume9en_US
dc.identifier.wosWOS:000178933900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmultiple sclerosis (MS)en_US
dc.subjectexperimental autoimmune encephalomyelitisen_US
dc.subjectnitric oxideen_US
dc.subjectnitriteen_US
dc.subjectnitrateen_US
dc.titleSerum nitric oxide metabolites in patients with multiple sclerosisen_US
dc.typeArticleen_US

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