The effects of calcium channel antagonist nimodipine on end-plate vascularity of the degenerated intervertebral disc in rats

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dc.contributor.authorTurgut, M
dc.contributor.authorUysal, A
dc.contributor.authorUslu, S
dc.contributor.authorTavus, N
dc.contributor.authorYurtseven, ME
dc.date.accessioned2019-10-27T18:40:31Z
dc.date.available2019-10-27T18:40:31Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description37th National Annual Neurological Congress -- OCT 31-NOV 04, 2001 -- ANTALYA, TURKEYen_US
dc.description.abstractThe vascular channels at the end-plate of the intervertebral disc are very important in maintaining a healthy disc. With age, a reduction of the nutrition of the avascular nucleus pulposus is inevitable. On the other hand the calcium channel antagonist nimodipine has been shown to have a positive effect on blood flow in the region of the vertebral end-plate. To evaluate the effects of nimodipine on the end-plate vascularity in the degenerative discs, We have produced an experimental disc degeneration and evaluated the radiological and histopathological features of the end-plate of the degenerated discs. Adult rats were divided into 3 groups: control (n = 5), operated degeneration (n = 5), and nimodipine treatment (n = 5). Using a posterior approach, a cut was made parallel to the end-plates in the posterior annulus fibrosus in 5 consecutive intervertebral discs between the 5th and 10th vertebral segments of the tails of adult Swiss Albino rats. At 8 weeks, 5 of these animals were treated with nimodipine. In each experimental group, 1 animal was examined using computed tomography (CT) to study the density of the cartilage end-plate of the disc. Then, the animals were sacrificed for subsequent histopathological evaluation. We found that the vascular channel counts and percentage areas from animals treated with nimodipine were higher than from both the non-operative control and operated degeneration groups, although these were not statistically different. Accordingly, the profile of the density histogram in the nimodipine-treated group showed a wide plateau, indicating an increase in the vascularity in this region. From our results, we suggest that nimodipine enhances vascularisation of the cartilage end-plate in the disc. It is possible that the increased proportion of vascular contacts at the end-plate has a beneficial effect in the nutrition of the disc. However, further experimental studies will be needed to determine the validity of this statement in animals or human beings. (C) 2003 Elsevier Science Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0967-5868(02)00336-3en_US
dc.identifier.endpage223en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue2en_US
dc.identifier.pmid12637054en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.1016/S0967-5868(02)00336-3
dc.identifier.urihttps://hdl.handle.net/11454/36914
dc.identifier.volume10en_US
dc.identifier.wosWOS:000181878600017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcartilage end-plateen_US
dc.subjectintervertebral discen_US
dc.subjectnimodipineen_US
dc.subjectvascular channelsen_US
dc.titleThe effects of calcium channel antagonist nimodipine on end-plate vascularity of the degenerated intervertebral disc in ratsen_US
dc.typeArticleen_US

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