A correlative study between 99mTc-ESTCPTA and 99mTc-MIBI in rats

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dc.contributor.authorUnak P.
dc.contributor.authorEnginar H.
dc.contributor.authorZümrüt Biber F.
dc.contributor.authorYurt Lambrecht F.
dc.contributor.authorAslani M.A.A.
dc.contributor.authorOzkilic H.
dc.date.accessioned2019-10-27T08:59:55Z
dc.date.available2019-10-27T08:59:55Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractTissue distribution of the 99mTc labeled derivative of the estrogen compound 3,17-?-estradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid) ester (ESTCPTA), which has an 3,17-?-estradiolyl propinol coupled to 1-(4-methylbenzoic acid)1,4,8,11-tetraazacyclotetradecane (CPTA), was compared to 99mTc-MIBI (methoxyisobutyl isonitrile) in female Albino Wistar rats. Tissues of interest included lung, liver, heart, kidneys, spleen, stomach, intestines, pancreas, muscle, blood, breast, ovary, fat, and uterus. 99mTc-ESTCPTA uptake by the uterus and ovary, as ER-rich tissues, was highly selective. Maximum uptakes for 99mTc-MIBI and 99mTc-ESTCPTA are 90min in breast, ovary and uterus. The pancreas also showed significant receptor saturated and unsaturated ratios for 99mTc-ESTCPTA. Results are sufficiently encouraging to generate further evaluation of these and related compounds as possible estrogen receptor based tumor imaging and therapeutic agents in estrogen-rich tissues. © 2002 Published by Elsevier Science Ltd.en_US
dc.identifier.doi10.1016/S0969-8043(02)00190-2en_US
dc.identifier.endpage742en_US
dc.identifier.issn0969-8043
dc.identifier.issue5en_US
dc.identifier.pmid12433049en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage733en_US
dc.identifier.urihttps://doi.org/10.1016/S0969-8043(02)00190-2
dc.identifier.urihttps://hdl.handle.net/11454/27937
dc.identifier.volume57en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofApplied Radiation and Isotopesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectERen_US
dc.subjectEstrogen derivativesen_US
dc.subjectEstrogen receptoren_US
dc.subjectEthynyl estradiolen_US
dc.subjectRaten_US
dc.subjectTc-99m labeled ESTCPTAen_US
dc.subjectTc-99m labeled MIBIen_US
dc.titleA correlative study between 99mTc-ESTCPTA and 99mTc-MIBI in ratsen_US
dc.typeArticleen_US

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