Anthracycline Chemotherapy-Induced Electro-Mechanical Changes: Strain Echocardiography Combined with Repolarization Parameters on Electrocardiography to Predict Early Cardiotoxicity

Basit Öğe Kaydı
dc.authorscopusid57200652121
dc.authorscopusid23568467100
dc.authorscopusid56695369700
dc.authorscopusid24402531400
dc.authorscopusid6603575068
dc.contributor.authorOzbay, Benay
dc.contributor.authorSimsek, Evrim
dc.contributor.authorKemal, Hatice
dc.contributor.authorCakar, Burcu
dc.contributor.authorYavuzgil, Oguz
dc.date.accessioned2023-01-12T20:18:57Z
dc.date.available2023-01-12T20:18:57Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: The aim of the study was to describe the acute cardiotoxic effects of anthracycline chemotherapy in echocardiographic strain and electrocardiographic repolarization parameters in patients with breast cancer. Methods: A total of 35 consecutive patients (all females, mean age: 48.9 +/- 11.8 years) who received chemotherapy due to breast cancer were prospectively included. Pre-treatment (T0) and third month (T2) 2-dimensional strain echocardiography and electrocardiography were performed. Additionally, within 3 hours of the first dose of chemotherapy (T1), additional electrocardiographic images were obtained. All mechanical and electrical parameters from different time intervals (T0, T1, and T2) were compared with each other. Results: In the acute period after treatment, electrocardiographic repolarization parameters were prolonged and this prolongation continued to the third month (QT corrected with Bazett formula [440.10 +/- 27.63 (T0), 468.00 +/- 38.98 (T1), 467.86 +/- 35.09 (T2)], QT dispersion [49.85 +/- 19.52 (T0), 69.54 +/- 16.06 (T1), 57.63 +/- 14.42 (T2)], and T-wave peak-to-end interval [94.00 +/- 45.46 (T0), 131.20 +/- 17.79 (T1), 120.00 +/- 18.32 (T2)]; P <.001). There was no significant change in global longitudinal strain values before and after treatment (global longitudinal strain avg: -21 +/- 7.1%; P =.8). However, there were significant reductions in strain parameters including circumferential and radial strain, and torsion (-17.2 +/- 3.5 to -13 +/- 2.84; P <.001, 45.1 +/- 8.3 to 35.6 +/- 10; P <.001, and 12.1 +/- 3.5 to 7.7 +/- 2.1; P <.001, respectively). Conclusion: Both the electrical and mechanical functions of the heart can be impaired acutely extending to 3 months after anthracycline chemotherapy. Therefore, cardiotoxicity should be evaluated early both electrically and mechanically after chemotherapy.en_US
dc.identifier.doi10.5543/tkda.2022.22359
dc.identifier.endpage+en_US
dc.identifier.issn1016-5169
dc.identifier.issue7en_US
dc.identifier.pmid35976235en_US
dc.identifier.scopus2-s2.0-85139573200en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage478en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2022.22359
dc.identifier.urihttps://hdl.handle.net/11454/78983
dc.identifier.volume50en_US
dc.identifier.wosWOS:000865992400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardio-oncologyen_US
dc.subjectcardiotoxicityen_US
dc.subjectelectro-mechanical dysfunctionen_US
dc.subjectstrain echocardiographyen_US
dc.subjectAmerican Societyen_US
dc.subjectEuropean Associationen_US
dc.subjectCancer-Patientsen_US
dc.subjectLymphomaen_US
dc.subjectPreventionen_US
dc.subjectGuidelinesen_US
dc.subjectCardiologyen_US
dc.subjectConsensusen_US
dc.subjectSurvivorsen_US
dc.subjectTherapyen_US
dc.titleAnthracycline Chemotherapy-Induced Electro-Mechanical Changes: Strain Echocardiography Combined with Repolarization Parameters on Electrocardiography to Predict Early Cardiotoxicityen_US
dc.title.alternativeAntrasiklinlere Bağlı Elektro-Mekanik Değişiklikler: Kardiyotoksisiteyi Erken Dönemde Öngörmede Strain Ekokardiyografinin Repolarizasyon Belirteçleri ile Birlikte Kullanımıen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu