Intracellular localization of beta-catenin expression plays a possible prognostic role on the outcome of hepatoblastoma patients

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dc.contributor.authorCeltik, Ulgen
dc.contributor.authorDokumcu, Zafer
dc.contributor.authorDivarci, Emre
dc.contributor.authorGuler, Ezgi
dc.contributor.authorAtaseven, Eda
dc.contributor.authorNart, Deniz
dc.contributor.authorErgun, Orkan
dc.date.accessioned2020-12-01T12:01:16Z
dc.date.available2020-12-01T12:01:16Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose Wnt/Beta-catenin pathway plays an essential role in liver development and regeneration. Abnormal activation in this pathway leads to development of hepatoblastoma (HB). Although its importance has invoked attention, its prognostic role is debatable. We aimed to evaluate the significance of intracellular localization of beta-catenin (BC) expression in the outcome of hepatoblastoma patients. Methods Medical records of HB patients between 2004 and 2018 were reviewed. Patients were grouped according to intracellular localization of BC expression by immunohistochemistry as being cytoplasmic or nuclear. Demographics, radiological images, PRETEXT classifications, vascular involvement, risk groups, chemotherapy responses, and survival rates were analyzed and compared between groups. Results There were 41 patients. Thirteen patients were excluded for unavailability of records in four, negative/unclear BC expressions in seven. Cytoplasmic expression of BC was observed in 17 patients whereas 13 patients displayed nuclear expression. Demographics were similar in both groups. Cytoplasmic BC expression was associated with poor chemotherapy response (p = 0.001) and increased vascular involvement (p = 0.0162) requiring more extensive surgeries (p = 0.039). Conclusion Although the numbers are limited in our series, the intracellular localization of BC expression has been found to be a promising determining factor for hepatoblastoma prognosis. With larger patient series, more reliable results can be achieved.en_US
dc.identifier.doi10.1007/s00383-020-04672-6en_US
dc.identifier.endpage825en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue7en_US
dc.identifier.pmid32436062en_US
dc.identifier.scopus2-s2.0-85084983442en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage817en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-020-04672-6
dc.identifier.urihttps://hdl.handle.net/11454/62367
dc.identifier.volume36en_US
dc.identifier.wosWOS:000534437900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatoblastomaen_US
dc.subjectBeta-cateninen_US
dc.subjectChildhood liver tumoren_US
dc.subjectImmunohistochemistryen_US
dc.subjectPrognosisen_US
dc.titleIntracellular localization of beta-catenin expression plays a possible prognostic role on the outcome of hepatoblastoma patientsen_US
dc.typeArticleen_US

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