P53 protein expression in eccrine poroma and porocarcinoma

Basit Öğe Kaydı
dc.contributor.authorAkalin, T
dc.contributor.authorSen, S
dc.contributor.authorYuceturk, A
dc.contributor.authorKandiloglu, G
dc.date.accessioned2019-10-27T18:19:17Z
dc.date.available2019-10-27T18:19:17Z
dc.date.issued2001
dc.departmentEge Üniversitesien_US
dc.description.abstractThe role of p53 mutation has been shown in different human malignancies, including various skin cancers. In this study, we examined p53 protein expression in 25 eccrine poromas and 11 porocarcinomas by immunohistochemistry. P53 expression was observed in 88% (22 of 25) of eccrine poromas and 73% (8 of 11) of porocarcinomas. In eccrine poromas, percentage of cells reactive for p53 was less than 5% (low expresser) in 6 cases, 5 to 50% (moderate expresser) in 14 and greater than 50% (high expresser) in 2 cases. In terms of intensity, 13 cases showed weak staining, 8 moderate, and 1 case showed strong reactivity. On the other hand, 2 cases of porocarcinoma were low expresser, 2 were moderate and 4 were high expresser. All of the high expressers had also strong staining. This study has demonstrated that eccrine poromas showed significant p53 expression as much as porocarcinomas and, therefore, p53 positivity cannot be accepted as a valuable parameter for malignancy. P53 gene may involve in the carcinogenetic pathway of porocarcinoma but it is likely that other oncogenes may also have a role.en_US
dc.identifier.doi10.1097/00000372-200110000-00003en_US
dc.identifier.endpage406en_US
dc.identifier.issn0193-1091
dc.identifier.issue5en_US
dc.identifier.pmid11801771en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage402en_US
dc.identifier.urihttps://doi.org/10.1097/00000372-200110000-00003
dc.identifier.urihttps://hdl.handle.net/11454/35636
dc.identifier.volume23en_US
dc.identifier.wosWOS:000171375200003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal of Dermatopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecteccrine poromaen_US
dc.subjectimmunohistochemistryen_US
dc.subjectp53en_US
dc.subjectporocarcinomaen_US
dc.titleP53 protein expression in eccrine poroma and porocarcinomaen_US
dc.typeArticleen_US

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