Epidemiology,natural course, and preventive measures of osteoporotic vertebral fractures: WFNS Spine Committee Recommendations

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dc.authorscopusid7004827180
dc.authorscopusid18534714000
dc.authorscopusid26436305900
dc.authorscopusid54398196400
dc.authorscopusid56021763700
dc.authorscopusid36106450200
dc.contributor.authorZileli, Mehmet
dc.contributor.authorFornari, Maurizio
dc.contributor.authorCosta, Francesco
dc.contributor.authorAnania, Carla D.
dc.contributor.authorParthiban, Jutty
dc.contributor.authorSharif, Salman
dc.date.accessioned2023-01-12T20:12:05Z
dc.date.available2023-01-12T20:12:05Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractINTRODUCTION: This review aims to search for up-to-date information on epidemiology, natural course, and preventive measures of osteoporotic spine fractures. EVIDENCE ACQUISITION: We reviewed the literature of the last ten years using keywords natural course and osteoporotic vertebral fractures, epidemiology and osteoporotic vertebral fractures and prevention and osteoporotic vertebral fractures. We then discussed the search results to reach an agreement in two consensus meetings on January and February 2021 of the World Federation of Neurosurgical Societies (WENS) Spine Committee. Finally, we utilized the Delphi method to administer the questionnaire to preserve a high degree of validity. We summarized seven papers on the natural course, 15 articles on epidemiology, and 84 papers on preventing osteoporotic vertebral fractures. Finally, the consensus results after voting are presented. EVIDENCE SYNTHESIS: Natural course of acute osteopomtic vertebral fractures is benign; many patients may have sufficient pain relief during the first three months with conservative treatment. At the end of one year of conservative treatment, 40% may still have pain with VAS-scores >= 4. Since the populations are aging, the incidence of OVF continues to rise. Although the prevalence varies across the globe, the highest rates are from North America and some countries of Asia. Preventive treatment of OVF must involve an active lifestyle, adequate nutrition, prevention of immobilization with physical therapy. and pharmacological therapy. Oral calcium and vitamin D are first-line interventions to prevent the bone mass loss, especially in postmenopausal women. There are many pharmacological treatment options: the decision must be made by fracture risk assessment (clinical factors + BMD + BMI) alone or along with DXA (dual-energy X-ray absorptiometry) or history of previous fragility fractures. The indication of one respect to the others is based on patient preference, compliance, and risk of discontinuation related to adverse events and administration method. CONCLUSIONS: The incidence of osteopomtic vertebral fractures increases with age and other factors. The natural course shows that most patients benefit from conservative therapy without any surgical intervention during the first three months. Preventive measures must include active lifestyle, adequate nutrition, prevention of immobilization with physical therapy, oral calcium, and vitamin D intake, and pharmacological therapy after fracture risk assessment.en_US
dc.identifier.doi10.23736/S0390-5616.22.05643-0
dc.identifier.endpage290en_US
dc.identifier.issn0390-5616
dc.identifier.issn1827-1855
dc.identifier.issue4en_US
dc.identifier.pmid35301844en_US
dc.identifier.scopus2-s2.0-85139374878en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage282en_US
dc.identifier.urihttps://doi.org/10.23736/S0390-5616.22.05643-0
dc.identifier.urihttps://hdl.handle.net/11454/78244
dc.identifier.volume66en_US
dc.identifier.wosWOS:000891143000002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofJournal of Neurosurgical Sciencesen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsteoporosisen_US
dc.subjectSpinal fracturesen_US
dc.subjectEpidemiologyen_US
dc.subjectPrevention and controlen_US
dc.subjectWomenen_US
dc.subjectPainen_US
dc.subjectMedicationsen_US
dc.subjectPrevalenceen_US
dc.subjectEfficacyen_US
dc.subjectDrugsen_US
dc.titleEpidemiology,natural course, and preventive measures of osteoporotic vertebral fractures: WFNS Spine Committee Recommendationsen_US
dc.typeReviewen_US

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