Apoptotic effects of thymol, a novel monoterpene phenol, on different types of cancer

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dc.contributor.authorElbe E.
dc.contributor.authorYigitturk G.
dc.contributor.authorCavusoglu T.
dc.contributor.authorUyanikgil Y.
dc.date.accessioned2021-05-03T20:54:11Z
dc.date.available2021-05-03T20:54:11Z
dc.date.issued2020
dc.description.abstractBACKGROUND: Cancer is a major public health problem in many areas of the world. Many anticancer drugs in current clinical use have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) is an oxygenated aromatic compound from monoterpene group. It is the main constituent of thyme essential oil and shows antioxidant, antiseptic and antiproliferative properties. The aim of this study is to determine the antiproliferative activity and apoptotic effect of thymol on prostate cancer (PC-3, DU145), breast cancer (MDA-MB-231), and lung cancer (KLN205) cell lines. METHODS: The cancer cells were treated with different concentrations of thymol (100, 200, 400, 600, 800 pM) at 24 h, 48 h and 72 h. The cell viability was investigated by MTT assay and analysis of apoptosis was determined with annexin V assay. RESULTS: The study showed the dose and time-dependent cytotoxic effect of thymol in PC-3, DU145, MDA-MB-231, and KLN205 cancer cell lines. Thymol significantly induced apoptosis in all groups in a dose-dependent manner. Statistical analysis showed a significant difference between thymol-treated cell lines compared to the control (p < 0.001). CONCLUSION: The data in the present study demonstrated that thymol has apoptotic and antiproliferative properties in lung, breast and prostate cancer cell lines. Thymol could serve as a potential therapeutic agent in the future (Fig. 5, Ref. 26). Text in PDF www.elis.sk. © 2020, Bratislava Medical Journal. All rights reserved.en_US
dc.identifier.doi10.4149/BLL_2020_016en_US
dc.identifier.endpage128en_US
dc.identifier.issn0006-9248
dc.identifier.issue2en_US
dc.identifier.pmid32115964en_US
dc.identifier.scopus2-s2.0-85080840846en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_016
dc.identifier.urihttps://hdl.handle.net/11454/71229
dc.identifier.volume121en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius University in Bratislavaen_US
dc.relation.ispartofBratislava Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantiproliferativeen_US
dc.subjectapoptosisen_US
dc.subjectcanceren_US
dc.subjectthymolen_US
dc.titleApoptotic effects of thymol, a novel monoterpene phenol, on different types of canceren_US
dc.typeArticleen_US

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