The Levels of Glutathione and Nitrite-Nitrate and the Expression of BCL-2 MRNA in Ovariectomized Rats Treated by Raloxifene Against Kainic Acid

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dc.contributor.authorArmagan, Guliz
dc.contributor.authorKanit, Lutfiye
dc.contributor.authorTerek, Cosan M.
dc.contributor.authorSozmen, Eser Y.
dc.contributor.authorYalcin, Ayfer
dc.date.accessioned2019-10-27T20:20:45Z
dc.date.available2019-10-27T20:20:45Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractThe selective estrogen receptor modulators (SERMs) are compounds that activate the estrogen receptors with different estrogenic and antiestrogenic tissue-specific effects. The similar effects of SERMs on estrogen encourage the efforts in the research of neuroprotective effects of SERMs. In our study, the potential neuroprotective effects of raloxifene were investigated on the brain cortex of ovariectomized rats after kainic acid-induced oxidative stress. To show the neuroprotective effect of raloxifene against a neurodegenerative agent, kainic acid, expression of Bcl-2, total glutathione (GSH), and nitrite-nitrate levels were investigated in the rat brain cortex. Our results demostrate that raloxifene treatment against oxidative stress significantly increases the expression of Bcl-2 and the level of GSH in the brain cortex.en_US
dc.description.sponsorshipEge University Scientific Research FoundationEge University; Turkish Scientific and Technological Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis study was supported by the Ege University Scientific Research Foundation and a scholarship for postgraduate students awarded to Guliz Armagan by the Turkish Scientific and Technological Council (TUBITAK).en_US
dc.identifier.doi10.1080/00207450802330959en_US
dc.identifier.endpage239en_US
dc.identifier.issn0020-7454
dc.identifier.issue2en_US
dc.identifier.pmid19125376en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://doi.org/10.1080/00207450802330959
dc.identifier.urihttps://hdl.handle.net/11454/41665
dc.identifier.volume119en_US
dc.identifier.wosWOS:000262183100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbrain cortexen_US
dc.subjectBcl-2en_US
dc.subjectglutathioneen_US
dc.subjectkainic aciden_US
dc.subjectovariectomyen_US
dc.subjectraloxifeneen_US
dc.titleThe Levels of Glutathione and Nitrite-Nitrate and the Expression of BCL-2 MRNA in Ovariectomized Rats Treated by Raloxifene Against Kainic Aciden_US
dc.typeArticleen_US

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