Bioavailability of 99mTc-paclitaxel-glucuronide ( 99mTc-PAC-G)
| dc.contributor.author | Muftuler F.Z.B. | |
| dc.contributor.author | Demir I. | |
| dc.contributor.author | Ünak P. | |
| dc.contributor.author | Içhedef Ç. | |
| dc.contributor.author | Kilçar A.Y. | |
| dc.date.accessioned | 2019-10-27T08:33:51Z | |
| dc.date.available | 2019-10-27T08:33:51Z | |
| dc.date.issued | 2011 | |
| dc.department | Ege Üniversitesi | en_US |
| dc.description.abstract | An antitumor agent paclitaxel (PAC) has been proved to be efficient in the treatment of breast and ovarian cancer. Glucuronic acid-derived paclitaxel compound (paclitaxel-glucuronide (PAC-G)) was enzymatically synthesized using microsome preparate separated from rat livers. The biodistribution mechanism of PAC-G in healthy female Albino Wistar rats has been investigated. The expected structure is confirmed according to LC/MS results, and the possible attachment is to C2-hydroxyl group. PAC-G was labeled with 99mTc and the radiochemical yield of radiolabeled compound (99mTc-PAC-G) was 98.00 ±2.74% (n = 9). The range of the breast/blood and breast/muscle ratios is approximately between 3 and 35 in 240 min. All these experimental studies indicate that 99mTc-PAC-G may potentially be used in breast tissue as an imaging agent. © by Oldenbourg Wissenschaftsverlag, München. | en_US |
| dc.description.sponsorship | 06 DPT 06 2008 NBE 008 | en_US |
| dc.description.sponsorship | Acknowledgment. We thank MS student Hasan ZORA and Eser UÇAR for technical help. This work was supported by T.R. Prime Ministry State Planning Organization (contract no 06 DPT 06) and Ege University Research Fund (contract no 2008 NBE 008). -- | en_US |
| dc.identifier.doi | 10.1524/ract.2011.1827 | |
| dc.identifier.endpage | 306 | en_US |
| dc.identifier.issn | 0033-8230 | |
| dc.identifier.issn | 0033-8230 | en_US |
| dc.identifier.issue | 5 | en_US |
| dc.identifier.scopusquality | Q3 | en_US |
| dc.identifier.startpage | 301 | en_US |
| dc.identifier.uri | https://doi.org/10.1524/ract.2011.1827 | |
| dc.identifier.uri | https://hdl.handle.net/11454/26901 | |
| dc.identifier.volume | 99 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Radiochimica Acta | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Bioavailability of 99mTc-paclitaxel-glucuronide ( 99mTc-PAC-G) | en_US |
| dc.type | Article | en_US |
