Bioavailability of 99mTc-paclitaxel-glucuronide ( 99mTc-PAC-G)
Küçük Resim Yok
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
An antitumor agent paclitaxel (PAC) has been proved to be efficient in the treatment of breast and ovarian cancer. Glucuronic acid-derived paclitaxel compound (paclitaxel-glucuronide (PAC-G)) was enzymatically synthesized using microsome preparate separated from rat livers. The biodistribution mechanism of PAC-G in healthy female Albino Wistar rats has been investigated. The expected structure is confirmed according to LC/MS results, and the possible attachment is to C2-hydroxyl group. PAC-G was labeled with 99mTc and the radiochemical yield of radiolabeled compound (99mTc-PAC-G) was 98.00 ±2.74% (n = 9). The range of the breast/blood and breast/muscle ratios is approximately between 3 and 35 in 240 min. All these experimental studies indicate that 99mTc-PAC-G may potentially be used in breast tissue as an imaging agent. © by Oldenbourg Wissenschaftsverlag, München.
Açıklama
Anahtar Kelimeler
Kaynak
Radiochimica Acta
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
99
Sayı
5
