Effect of octreotide on oxidative stress in the erythrocyte and kidney tissue in adriamycin-induced experimental nephrotic model

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dc.authoridGarip Acar, Alev/0000-0002-9377-7921
dc.authoridSen, Sait/0000-0002-1100-6657
dc.authoridAkcay, Yasemin/0000-0002-0497-9346
dc.authoridCavdar, Sibel/0000-0002-4570-3071
dc.authoridhur, ender/0000-0002-8066-4629
dc.contributor.authorCavdar, Sibel
dc.contributor.authorAcar, Alev Garip
dc.contributor.authorCamyar, Asuman
dc.contributor.authorHur, Ender
dc.contributor.authorSozmen, Eseryildirim
dc.contributor.authorSen, Sait
dc.contributor.authorOzisik, Melih
dc.date.accessioned2024-08-31T07:49:47Z
dc.date.available2024-08-31T07:49:47Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Nephrotic syndrome (NS) is one of the reasons of end -stage kidney disease, and elucidating the pathogenesis and offer new treatment options is important. Oxidative stress might trigger pathogenesis systemically or isolated in the kidneys. Octreotide (OCT) has beneficial antioxidant effects. We aimed to investigate the source of oxidative stress and the effect of OCT on experimental NS model. Methods: Twenty-four nonuremic Wistar albino rats were divided into 3 groups. Control group, 2 mL saline intramuscular (im); NS group, adriamycin 5 mg/kg intravenous (iv); NS treatment group, adriamycin 5 mg/kg (iv) and OCT 200 mcg/kg (im) were administered at baseline (Day 0). At the end of 21 days, creatinine and protein levels were measured in 24 -hour urine samples. Erythrocyte and renal catalase (CAT) and thiobarbituric acid reactive substance (TBARS) were measured. Renal histology was also evaluated. Results: There was no significant difference among the 3 groups in terms of CAT and TBARS in erythrocytes. Renal CAT level was lowest in NS group, and significantly lower than the control group. In treatment group, CAT level significantly increased compared with NS group. In terms of renal histology, tubular and interstitial evaluations were similar in all groups. Glomerular score was significantly higher in NS group compared with control group and it was significantly decreased in treatment group compared to NS group. Conclusions: Oxidative stress in NS might be due to the decrease in antioxidant protection mechanism in kidney. Octreotide improves antioxidant levels and histology in renal tissue and might be a treatment option.en_US
dc.description.sponsorshipEge University Project Research and Support Fund [2011 -TIP -060]en_US
dc.description.sponsorshipThis study was supported by the Ege University Project Research and Support Fund (Project No: 2011 -TIP -060) .en_US
dc.identifier.doi10.1590/2175-8239-JBN-2022-0180en
dc.identifier.endpage28en_US
dc.identifier.issn0101-2800
dc.identifier.issn2175-8239
dc.identifier.issue1en_US
dc.identifier.pmid37527531en_US
dc.identifier.scopus2-s2.0-85185773018en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage18en_US
dc.identifier.urihttps://doi.org/10.1590/2175-8239-JBN-2022-0180en
dc.identifier.urihttps://hdl.handle.net/11454/104998
dc.identifier.volume46en_US
dc.identifier.wosWOS:001183550200003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasileira Nefrologiaen_US
dc.relation.ispartofJornal Brasileiro De Nefrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectNephrotic Syndromeen_US
dc.subjectOctreotideen_US
dc.subjectReactive Oxygen Speciesen_US
dc.subjectCatalaseen_US
dc.subjectThiobarbituric Acid Reactive Substanceen_US
dc.subjectOxidative Stressen_US
dc.titleEffect of octreotide on oxidative stress in the erythrocyte and kidney tissue in adriamycin-induced experimental nephrotic modelen_US
dc.typeArticleen_US

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