The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link?

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dc.contributor.authorMakay, Balahan
dc.contributor.authorMakay, Ozer
dc.contributor.authorYenisey, Cigdem
dc.contributor.authorIcoz, Gokhan
dc.contributor.authorOzgen, Gokhan
dc.contributor.authorUnsal, Erbil
dc.contributor.authorAkyildiz, Mahir
dc.contributor.authorYetkin, Enis
dc.date.accessioned2019-10-27T20:21:23Z
dc.date.available2019-10-27T20:21:23Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractOxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were divided into three groups. Group A served as negative controls. Group B had untreated thyrotoxicosis, and Group C received melatonin. Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO(center dot)x), and plasma IL-6, IL-10, and TNF-alpha were measured. MDA, GSH, NO(center dot)x, IL-10, and TNF-alpha levels increased after L-thyroxine induction. An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration. MDA, GSH, and NO(center dot)x levels were also affected by melatonin. Lowest TNFalpha levels were observed in Group C. This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat. Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response. Copyright (C) 2009 Balahan Makay et al.en_US
dc.identifier.doi10.1155/2009/391682en_US
dc.identifier.issn0962-9351
dc.identifier.pmid19343192en_US
dc.identifier.urihttps://doi.org/10.1155/2009/391682
dc.identifier.urihttps://hdl.handle.net/11454/41753
dc.identifier.wosWOS:000265049600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofMediators of Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link?en_US
dc.typeArticleen_US

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