Plasma catalase, glutathione peroxidase and selenium levels in adult diabetic patients

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dc.contributor.authorSara Habif
dc.contributor.authorNevbahar Turgan
dc.contributor.authorIşıl Mutaf
dc.contributor.authorFigen Aytaçlar
dc.contributor.authorFüsun Hamulu
dc.contributor.authorOya Bayındır
dc.contributor.authorCandeğer Yılmaz
dc.date.accessioned2019-10-26T19:53:58Z
dc.date.available2019-10-26T19:53:58Z
dc.date.issued1997
dc.departmentEge Üniversitesien_US
dc.description.abstractDiabetes mellitus is not simply a disorder of glucose homeostasis, but is also accompanied by various degenerative manifestations, such as cardiovascular disease and microvascular lesions leading to retinopathy and glomerulopathy. These events may be related to the hyperproduction of free radicals and to a deficiency in available antioxidant systems like low enzyme activity or deficient micronutrient status. To test the feasibility of this idea, we compared the activities of plasma catalase and glutathione peroxidase, as well as the latterÕs cofactor, selenium in diabetics (n=14) and age-matched healthy controls (n=12). The antioxidant enzyme activity in the diabetics was generally lower than in the controls. The following results were obtained: (mean±SEM, controls and diabetics, respectively): plasma catalase 154.02±13.71 kU/L and 114.31±17.60 kU/L (p<0.05); glutathione peroxidase 457.96+-22.66 U/L and 374.61+-21.88 U/L (p<0.05); selenium, 22.1+-2.53 and 17.4+-1.21 ng/mL (p<0.05). Our results suggest that increased oxidative activity, which leads to a depletion in antioxidant enzyme status, may play an important role in the pathogenesis of complications associated with chronic diabetes.en_US
dc.description.abstractDiabetes mellitus is not simply a disorder of glucose homeostasis, but is also accompanied by various degenerative manifestations, such as cardiovascular disease and microvascular lesions leading to retinopathy and glomerulopathy. These events may be related to the hyperproduction of free radicals and to a deficiency in available antioxidant systems like low enzyme activity or deficient micronutrient status. To test the feasibility of this idea, we compared the activities of plasma catalase and glutathione peroxidase, as well as the latterÕs cofactor, selenium in diabetics (n=14) and age-matched healthy controls (n=12). The antioxidant enzyme activity in the diabetics was generally lower than in the controls. The following results were obtained: (mean±SEM, controls and diabetics, respectively): plasma catalase 154.02±13.71 kU/L and 114.31±17.60 kU/L (p<0.05); glutathione peroxidase 457.96+-22.66 U/L and 374.61+-21.88 U/L (p<0.05); selenium, 22.1+-2.53 and 17.4+-1.21 ng/mL (p<0.05). Our results suggest that increased oxidative activity, which leads to a depletion in antioxidant enzyme status, may play an important role in the pathogenesis of complications associated with chronic diabetes.en_US
dc.identifier.endpage141en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRNeU1ESXk=
dc.identifier.urihttps://hdl.handle.net/11454/14019
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryDiğeren_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titlePlasma catalase, glutathione peroxidase and selenium levels in adult diabetic patientsen_US
dc.typeOtheren_US

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