Assessment of pituitary function in patients with nasopharyngeal carcinoma: the effect of radiotherapy

Basit Öğe Kaydı
dc.contributor.authorAkagunduz, Ozlem Ozkaya
dc.contributor.authorYurekli, Banu Sarer
dc.contributor.authorSimsir, Ilgin Yildirim
dc.contributor.authorEsassolak, Mustafa
dc.date.accessioned2020-12-01T12:37:15Z
dc.date.available2020-12-01T12:37:15Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractRadiotherapy (RT) plays a very important role in nasopharyngeal carcinoma (NPC). the pituitary gland can be affected by radiation due to its proximity to the nasopha-ryngeal cavity. Our aim is to demonstrate the effect of radiotherapy given for NPC on anterior pituitary function with basal pituitary hormones and provocative tests. Patients with NPC that were treated with definitive chemoradioherapy were reviewed retrospectively. Serum ACTH, GH, PRL, FSH, LH, TSH and cortisol, DHEAS, IGF-1, E2, testosterone, fT3, fT4 levels were recorded to evaluate pituitary function. Insulin tolerance test was performed to investigate hypothalamic-pituitary-adrenal axis and GH -IGF-1 axis. Comparison between early tumor stage and advanced tumor stage for pituitary dysfunction was done. the median time interval between the RT and endocrinologic evaluation was 4.0 (1-13) years. ACTH deficiency was found to be most common hormonal problem with a frequency of 73.7%. of these 71.4% were mild adrenal deficiencies. GH deficiency was seen in 60% of patients. fT3, TSH, GH and IGF-1 levels were significantly lower in patients with advanced tumor stage compared with early tumor stage (p = 0.033, p = 0.022, p = 0.043, p = 0.022, respectively). Growth hormone deficiency was found in all of advanced and in 43% of early tumor stage patients (p = 0.017). We found higher rates of ACTH and GH deficiencies followed by gonadotropin, corticotropin and thyrotropin deficiency. Basal pituitary hormones will not be sufficient to evaluate anterior pituitary failure. Annual and systematic dynamic tests together with basal anterior pituitary hormones would be neededen_US
dc.identifier.doi10.5455/medscience.2019.08.9032
dc.identifier.endpage553en_US
dc.identifier.issn2147-0634
dc.identifier.issn2147-0634
dc.identifier.issue3en_US
dc.identifier.startpage549en_US
dc.identifier.urihttps://doi.org/:10.5455/medscience.2019.08.9032
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TXpZek9UZzNOdz09
dc.identifier.urihttps://hdl.handle.net/11454/67135
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject0-Belirleneceken_US
dc.titleAssessment of pituitary function in patients with nasopharyngeal carcinoma: the effect of radiotherapyen_US
dc.typeArticleen_US

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