Tumor necrosis factor-?-converting enzyme (TACE) levels in periodontal diseases

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dc.contributor.authorBostanci N.
dc.contributor.authorEmingil G.
dc.contributor.authorAfacan B.
dc.contributor.authorHan B.
dc.contributor.authorIlgenli T.
dc.contributor.authorAtilla G.
dc.contributor.authorHughes F.J.
dc.contributor.authorBelibasakis G.N.
dc.date.accessioned2019-10-27T08:36:41Z
dc.date.available2019-10-27T08:36:41Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractTumor necrosis factor-?-converting enzyme (TACE) is a metalloprotease which can shed several cytokines from the cell membrane, including receptor activator of NF-?B ligand (RANKL). This study aimed to investigate the hypothesis that TACE would be elevated in the gingival crevicular fluid (GCF) of persons with periodontitis. Total TACE amounts in GCF were higher in persons with chronic and aggressive periodontitis than in those with gingivitis or in healthy persons. TACE concentrations in GCF were higher in persons with chronic and aggressive periodontitis than in those with gingivitis, although not significantly higher than in healthy persons. Persons with chronic periodontitis receiving immunosuppressive treatment exhibited over 10-fold lower TACE levels than the other periodontitis groups. TACE was positively correlated with probing pocket depth, clinical attachment levels, and RANKL concentrations in GCF. In conclusion, the increased GCF TACE levels in persons with periodontitis and their positive correlation with RANKL may indicate an association of this enzyme with alveolar bone loss, and may warrant special attention in future therapeutic approaches.en_US
dc.identifier.doi10.1177/154405910808700311en_US
dc.identifier.endpage277en_US
dc.identifier.issn0022-0345
dc.identifier.issue3en_US
dc.identifier.pmid18296613en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.1177/154405910808700311
dc.identifier.urihttps://hdl.handle.net/11454/27423
dc.identifier.volume87en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Dental Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone resorptionen_US
dc.subjectGingival crevicular fluiden_US
dc.subjectPeriodontal diseasesen_US
dc.subjectRANKLen_US
dc.subjectTACEen_US
dc.titleTumor necrosis factor-?-converting enzyme (TACE) levels in periodontal diseasesen_US
dc.typeArticleen_US

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